About: Genetic structure and contrasting selection pattern at two major histocompatibility complex genes in wild house mouse populations

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About: Genetic structure and contrasting selection pattern at two major histocompatibility complex genes in wild house mouse populations Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The mammalian major histocompatibility complex (MHC) is a tightly linked cluster of immune genes, and is often thought of as inherited as a unit. This has led to the hope that studying a single MHC gene will reveal patterns of evolution representative of the MHC as a whole. In this study we analyse a 1000-km transect of MHC variation in house mice to compare signals of selection and patterns of diversification at two closely linked MHC class II genes, H-2Aa and H-2Eb. We show that although they are 0.01cM apart, disparate evolutionary patterns were detected. H-2Aa shows higher allelic polymorphism, faster allelic turnover due to higher mutation rates, stronger positive selection at antigen-binding sites and higher population structuring than H-2Eb. H-2Eb alleles are maintained in the gene pool for longer, including over separation of the subspecies, some H-2Eb alleles are positively and others negatively selected and some of the alleles are not expressed. The mammalian major histocompatibility complex (MHC) is a tightly linked cluster of immune genes, and is often thought of as inherited as a unit. This has led to the hope that studying a single MHC gene will reveal patterns of evolution representative of the MHC as a whole. In this study we analyse a 1000-km transect of MHC variation in house mice to compare signals of selection and patterns of diversification at two closely linked MHC class II genes, H-2Aa and H-2Eb. We show that although they are 0.01cM apart, disparate evolutionary patterns were detected. H-2Aa shows higher allelic polymorphism, faster allelic turnover due to higher mutation rates, stronger positive selection at antigen-binding sites and higher population structuring than H-2Eb. H-2Eb alleles are maintained in the gene pool for longer, including over separation of the subspecies, some H-2Eb alleles are positively and others negatively selected and some of the alleles are not expressed. (en)
Title	Genetic structure and contrasting selection pattern at two major histocompatibility complex genes in wild house mouse populations Genetic structure and contrasting selection pattern at two major histocompatibility complex genes in wild house mouse populations (en)
skos:prefLabel	Genetic structure and contrasting selection pattern at two major histocompatibility complex genes in wild house mouse populations Genetic structure and contrasting selection pattern at two major histocompatibility complex genes in wild house mouse populations (en)
skos:notation	RIV/68081766:_____/11:00347205!RIV12-AV0-68081766
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA206/08/0640), P(IAA600930608), Z(AV0Z60930519)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Čížková, Dagmar Bryja, Josef Piálek, Jaroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav biologie obratlovců AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	201006
http://linked.open...ai/riv/idVysledku	RIV/68081766:_____/11:00347205
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	MHC; house mouse; selection; population structure; trans-species polymorphism (en)
http://linked.open.../riv/klicoveSlovo	MHC house mouse population structure trans-species polymorphism selection
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[39D289509B67]
http://linked.open...i/riv/nazevZdroje	Heredity
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Immunogenetic study of a house mouse hybrid zone The role of MHC in sexual selection - observational and experimental study in three model vertebrate species
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	106
http://linked.open...iv/tvurceVysledku	Baird, S. J. E. Bryja, Josef Piálek, Jaroslav Čížková, Dagmar Goüy de Bellocq, J.
http://linked.open...ain/vavai/riv/wos	000289713700005
http://linked.open...n/vavai/riv/zamer	Biodiverzita a ekologie obratlovců: Strategie ochrany a využívání přírodních populací
issn	0018-067X
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.1038/hdy.2010.112

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