About: QT Interval Analysis in Electrograms of Isolated Guinea Pig Hearts Treated with Haloperidol

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The influence of antipsychotic drug haloperidol on repolarization defined by QTc interval was analyzed in electrograms of 8 isolated guinea pig hearts. Each experiment consisted of four phases: stabilization (S), first haloperidol administration (H1), washout (W), and second haloperidol administration (H2). QTc was computed according to three correction models: Bazett’s, Fridericia’s and dynamic model based on transfer function (TRF). Mean value and standard deviation of QTc were assigned from the interval of 2000 beats in the middle of all four experimental phases. The inaccuracy of QTc given as STD/mean over all phases and experiments was 0.0160.013, 0.0150.010 and 0.00390.0024 for Bazett, Fridericia and TRF,respectively. The QTc prolongation by haloperidol was confirmed by TRF model. Relative QTcT prolongation caused by haloperidol was (H2-W 0.00620.0054, P=0.07) and shortening (H1-W -0.00380.0037, P=0.07) caused by washout. The QTcB and QTcF changes were given more by RR changes than haloperidol influence. The dynamic, subject specific model of QT/RR coupling must be used in drugs analysis. The influence of antipsychotic drug haloperidol on repolarization defined by QTc interval was analyzed in electrograms of 8 isolated guinea pig hearts. Each experiment consisted of four phases: stabilization (S), first haloperidol administration (H1), washout (W), and second haloperidol administration (H2). QTc was computed according to three correction models: Bazett’s, Fridericia’s and dynamic model based on transfer function (TRF). Mean value and standard deviation of QTc were assigned from the interval of 2000 beats in the middle of all four experimental phases. The inaccuracy of QTc given as STD/mean over all phases and experiments was 0.0160.013, 0.0150.010 and 0.00390.0024 for Bazett, Fridericia and TRF,respectively. The QTc prolongation by haloperidol was confirmed by TRF model. Relative QTcT prolongation caused by haloperidol was (H2-W 0.00620.0054, P=0.07) and shortening (H1-W -0.00380.0037, P=0.07) caused by washout. The QTcB and QTcF changes were given more by RR changes than haloperidol influence. The dynamic, subject specific model of QT/RR coupling must be used in drugs analysis. (en)
Title	QT Interval Analysis in Electrograms of Isolated Guinea Pig Hearts Treated with Haloperidol QT Interval Analysis in Electrograms of Isolated Guinea Pig Hearts Treated with Haloperidol (en)
skos:prefLabel	QT Interval Analysis in Electrograms of Isolated Guinea Pig Hearts Treated with Haloperidol QT Interval Analysis in Electrograms of Isolated Guinea Pig Hearts Treated with Haloperidol (en)
skos:notation	RIV/68081731:_____/13:00421204!RIV14-GA0-68081731
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP102/12/2034)
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Halámek, Josef
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav přístrojové techniky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	101124
http://linked.open...ai/riv/idVysledku	RIV/68081731:_____/13:00421204
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	QTc; isolated heart; haloperidol; QT/RR coupling (en)
http://linked.open.../riv/klicoveSlovo	QT/RR coupling QTc haloperidol isolated heart
http://linked.open...ontrolniKodProRIV	[F10F228BB12C]
http://linked.open...v/mistoKonaniAkce	Zaragoza
http://linked.open...i/riv/mistoVydani	Zaragoza
http://linked.open...i/riv/nazevZdroje	Computing in Cardiology /40./
http://linked.open...in/vavai/riv/obor	JA
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Analysis of Relationship between Electrical Activity and Blood Flow at the Heart Ventricles
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Krejčířová, L. Halámek, Josef Veselý, P. Nováková, M. Stračina, T.
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2013-09-22 (xsd:date)
issn	2325-8861
number of pages	4 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Computing in Cardiology

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