About: Comparing the Relationship between QT/RR Slope and Basal QTc in LQT1 Patients and Healthy Subjects

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About: Comparing the Relationship between QT/RR Slope and Basal QTc in LQT1 Patients and Healthy Subjects Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The dependency of the QT interval to the previous RR intervals has been widely studied, QT/RR slope and other modeling techniques revealed individual-specific relationship. In this work we studied the relationship between QT/RR slope and a basal QTc interval in 154 healthy subjects and in 97 patients with the inherited long QT syndrome type-1 (LQT1) to provide insights into the effect of the impairment of the outwardly directed delayed rectifier potassium current on the dynamic QT-RR coupling. QT/RR slope values show strong relationship to basal QTc interval in healthy (R=0.65; p<0.00001) and in LQT1 patients (R=0.56; p<0.00001). The dependency of QT/RR slope on QTc is steeper in healthy (a1=0.0016 0.0002) than in LQT1 (a1=0.0010 0.0002), p<0.0001. The steeper dependency on QTc in healthy preserves proper shortening of QT intervals during increased heart rate in healthy while in LQT1 patients the QT intervals does not adapt to increased heart rate sufficiently (lack of QT adaptation to heart rate acceleration). This observation is consistent with current clinical mechanism associated with the triggering of life-threatening arrhythmias in the LQTS type-1 patients The dependency of the QT interval to the previous RR intervals has been widely studied, QT/RR slope and other modeling techniques revealed individual-specific relationship. In this work we studied the relationship between QT/RR slope and a basal QTc interval in 154 healthy subjects and in 97 patients with the inherited long QT syndrome type-1 (LQT1) to provide insights into the effect of the impairment of the outwardly directed delayed rectifier potassium current on the dynamic QT-RR coupling. QT/RR slope values show strong relationship to basal QTc interval in healthy (R=0.65; p<0.00001) and in LQT1 patients (R=0.56; p<0.00001). The dependency of QT/RR slope on QTc is steeper in healthy (a1=0.0016 0.0002) than in LQT1 (a1=0.0010 0.0002), p<0.0001. The steeper dependency on QTc in healthy preserves proper shortening of QT intervals during increased heart rate in healthy while in LQT1 patients the QT intervals does not adapt to increased heart rate sufficiently (lack of QT adaptation to heart rate acceleration). This observation is consistent with current clinical mechanism associated with the triggering of life-threatening arrhythmias in the LQTS type-1 patients (en)
Title	Comparing the Relationship between QT/RR Slope and Basal QTc in LQT1 Patients and Healthy Subjects Comparing the Relationship between QT/RR Slope and Basal QTc in LQT1 Patients and Healthy Subjects (en)
skos:prefLabel	Comparing the Relationship between QT/RR Slope and Basal QTc in LQT1 Patients and Healthy Subjects Comparing the Relationship between QT/RR Slope and Basal QTc in LQT1 Patients and Healthy Subjects (en)
skos:notation	RIV/68081731:_____/13:00421200!RIV14-GA0-68081731
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP102/12/2034)
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Vondra, Vlastimil Jurák, Pavel Halámek, Josef
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav přístrojové techniky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	66116
http://linked.open...ai/riv/idVysledku	RIV/68081731:_____/13:00421200
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ventricular repolarization; QTc; coupling; QT/RR slope (en)
http://linked.open.../riv/klicoveSlovo	QTc coupling ventricular repolarization QT/RR slope
http://linked.open...ontrolniKodProRIV	[02754F6AEE3B]
http://linked.open...v/mistoKonaniAkce	Zaragoza
http://linked.open...i/riv/mistoVydani	Zaragoza
http://linked.open...i/riv/nazevZdroje	Computing in Cardiology /40./
http://linked.open...in/vavai/riv/obor	JA
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Analysis of Relationship between Electrical Activity and Blood Flow at the Heart Ventricles
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Halámek, Josef Jurák, Pavel Leinveber, P. Vondra, Vlastimil Couderc, J. P.
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2013-09-22 (xsd:date)
issn	2325-8861
number of pages	4 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Computing in Cardiology

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