About: Separation of nucleobases, nucleosides, and nucleotides using two zwitterionic silica-based monolithic capillary columns coupled with tandem mass spectrometry

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About: Separation of nucleobases, nucleosides, and nucleotides using two zwitterionic silica-based monolithic capillary columns coupled with tandem mass spectrometry Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://hdl.handle.net/11104/0242051
Description	tThe capability of employing synthesized zwitterionic silica-based monolithic capillary columns(140 mm 0.1 mm) for separation of highly polar and hydrophilic nucleobases, nucleosides, andnucleotides in hydrophilic interaction chromatography is reported. The suitability of the columns foron-line conjunction with electrospray tandem mass spectrometry was explored. Our results showthat the grafted layer of zwitterionic monomer ([2-(methacryloyloxy)ethyl]-dimethyl-(3-sulfopropyl)-ammonium hydroxide or 2-methacryloyloxyethyl phosphorylcholine) on the silica monolithic surfacesignificantly improved the separation selectivity and reproducibility, as compared to the bare silica mono-lith. The stepwise elution from 90% to 70% of acetonitrile enabled separation of a complex sample mixturecontaining 21 compounds with a total analysis time less than 40 min. tThe capability of employing synthesized zwitterionic silica-based monolithic capillary columns(140 mm 0.1 mm) for separation of highly polar and hydrophilic nucleobases, nucleosides, andnucleotides in hydrophilic interaction chromatography is reported. The suitability of the columns foron-line conjunction with electrospray tandem mass spectrometry was explored. Our results showthat the grafted layer of zwitterionic monomer ([2-(methacryloyloxy)ethyl]-dimethyl-(3-sulfopropyl)-ammonium hydroxide or 2-methacryloyloxyethyl phosphorylcholine) on the silica monolithic surfacesignificantly improved the separation selectivity and reproducibility, as compared to the bare silica mono-lith. The stepwise elution from 90% to 70% of acetonitrile enabled separation of a complex sample mixturecontaining 21 compounds with a total analysis time less than 40 min. (en)
Title	Separation of nucleobases, nucleosides, and nucleotides using two zwitterionic silica-based monolithic capillary columns coupled with tandem mass spectrometry Separation of nucleobases, nucleosides, and nucleotides using two zwitterionic silica-based monolithic capillary columns coupled with tandem mass spectrometry (en)
skos:prefLabel	Separation of nucleobases, nucleosides, and nucleotides using two zwitterionic silica-based monolithic capillary columns coupled with tandem mass spectrometry Separation of nucleobases, nucleosides, and nucleotides using two zwitterionic silica-based monolithic capillary columns coupled with tandem mass spectrometry (en)
skos:notation	RIV/68081715:_____/14:00438643!RIV15-MV0-68081715
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP106/12/0522), P(VG20112015021)
http://linked.open...iv/cisloPeriodika	Dec
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Planeta, Josef Moravcová, Dana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav analytické chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	44519
http://linked.open...ai/riv/idVysledku	RIV/68081715:_____/14:00438643
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HILIC separation; ESI–MS; Monolithic silica column (en)
http://linked.open.../riv/klicoveSlovo	Monolithic silica column ESI–MS HILIC separation
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[F4420EA65195]
http://linked.open...i/riv/nazevZdroje	Journal of Chromatography A
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	A green method to treat fused-silica and glass surfaces: supercritical water in the development of analytical separation devices Development of instrumental methods for rapid detection and identification of biological agens in field samples
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	1373
http://linked.open...iv/tvurceVysledku	Moravcová, Dana Planeta, Josef Hyötyläinen, T. Kostiainen, R. Wiedmer, S. K. Haapala, M.
http://linked.open...ain/vavai/riv/wos	000347265800011
issn	0021-9673
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.chroma.2014.11.015

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