About: Granulocyte Colony-Stimulating Factor in the Treatment of Acute Radiation Syndrome: A Concise Review

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This article concisely summarizes data on the action of one of the principal and best known growth factors, the granulocyte colony-stimulating factor (G-CSF), in a mammalian organism exposed to radiation doses inducing acute radiation syndrome. Highlighted are the topics of its real or anticipated use in radiation accident victims, the timing of its administration, the possibilities of combining G-CSF with other drugs, the ability of other agents to stimulate endogenous G-CSF production, as well as of the capability of this growth factor to ameliorate not only the bone marrow radiation syndrome but also the gastrointestinal radiation syndrome. G-CSF is one of the pivotal drugs in the treatment of radiation accident victims and its employment in this indication can be expected to remain or even grow in the future. This article concisely summarizes data on the action of one of the principal and best known growth factors, the granulocyte colony-stimulating factor (G-CSF), in a mammalian organism exposed to radiation doses inducing acute radiation syndrome. Highlighted are the topics of its real or anticipated use in radiation accident victims, the timing of its administration, the possibilities of combining G-CSF with other drugs, the ability of other agents to stimulate endogenous G-CSF production, as well as of the capability of this growth factor to ameliorate not only the bone marrow radiation syndrome but also the gastrointestinal radiation syndrome. G-CSF is one of the pivotal drugs in the treatment of radiation accident victims and its employment in this indication can be expected to remain or even grow in the future. (en)
Title	Granulocyte Colony-Stimulating Factor in the Treatment of Acute Radiation Syndrome: A Concise Review Granulocyte Colony-Stimulating Factor in the Treatment of Acute Radiation Syndrome: A Concise Review (en)
skos:prefLabel	Granulocyte Colony-Stimulating Factor in the Treatment of Acute Radiation Syndrome: A Concise Review Granulocyte Colony-Stimulating Factor in the Treatment of Acute Radiation Syndrome: A Concise Review (en)
skos:notation	RIV/68081707:_____/14:00435167!RIV15-GA0-68081707
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP303/11/0128)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Hoferová, Zuzana Pospíšil, Milan Hofer, Michal Komůrková, Denisa
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	18562
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/14:00435167
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	granulocyte colony-stimulating factor; radiation accidents; acute radiation syndrome (en)
http://linked.open.../riv/klicoveSlovo	acute radiation syndrome granulocyte colony-stimulating factor radiation accidents
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[D5F31EF2274B]
http://linked.open...i/riv/nazevZdroje	Molecules
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Role of adenosine A3 receptor signaling in regulation of hematopoiesis: knowledge obtained from adenosine A3 receptor knock-out mice
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	19
http://linked.open...iv/tvurceVysledku	Hofer, Michal Hoferová, Zuzana Pospíšil, Milan Komůrková, Denisa
http://linked.open...ain/vavai/riv/wos	000336087800060
issn	1420-3049
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.3390/molecules19044770

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