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rdf:type
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Description
| - The histamine H-4 receptor regulates the inflammatory response. However, it is not known whether this receptor has a functional role in human neutrophils. We found that fMLP (1 mu M), but not histamine (0.1-1 mu M), induced Mac-1-dependent adhesion, polarization, and degranulation (release of lactoferrin). A pretreatment of neutrophils with histamine (0.001-1 mu M) or JNJ 28610244 (0.1-10 mu M), a specific H-4 receptor agonist, led to inhibition of degranulation. Total inhibition of degranulation was obtained with 0.1 mu M histamine and 10 mu M JNJ 28610244. Furthermore, such inhibition by histamine of degranulation was reversed by JNJ 7777120 and JNJ 28307474, two selective H-4 receptor antagonists. However, neither histamine nor the H-4 receptor agonist JNJ 28610244 prevented fMLP-induced, Mac-1-dependent adhesion, indicating that the H-4 receptor may block signals emanating from Mac-1-controlling degranulation. Likewise, engagement of the H-4 receptor by the selective agonist JNJ 28610244 blocked Mac-1-dependent activation of p38 MAPK, the kinase that controls neutrophil degranulation.
- The histamine H-4 receptor regulates the inflammatory response. However, it is not known whether this receptor has a functional role in human neutrophils. We found that fMLP (1 mu M), but not histamine (0.1-1 mu M), induced Mac-1-dependent adhesion, polarization, and degranulation (release of lactoferrin). A pretreatment of neutrophils with histamine (0.001-1 mu M) or JNJ 28610244 (0.1-10 mu M), a specific H-4 receptor agonist, led to inhibition of degranulation. Total inhibition of degranulation was obtained with 0.1 mu M histamine and 10 mu M JNJ 28610244. Furthermore, such inhibition by histamine of degranulation was reversed by JNJ 7777120 and JNJ 28307474, two selective H-4 receptor antagonists. However, neither histamine nor the H-4 receptor agonist JNJ 28610244 prevented fMLP-induced, Mac-1-dependent adhesion, indicating that the H-4 receptor may block signals emanating from Mac-1-controlling degranulation. Likewise, engagement of the H-4 receptor by the selective agonist JNJ 28610244 blocked Mac-1-dependent activation of p38 MAPK, the kinase that controls neutrophil degranulation. (en)
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Title
| - The histamine H-4 receptor is a potent inhibitor of adhesion-dependent degranulation in human neutrophils
- The histamine H-4 receptor is a potent inhibitor of adhesion-dependent degranulation in human neutrophils (en)
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skos:prefLabel
| - The histamine H-4 receptor is a potent inhibitor of adhesion-dependent degranulation in human neutrophils
- The histamine H-4 receptor is a potent inhibitor of adhesion-dependent degranulation in human neutrophils (en)
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skos:notation
| - RIV/68081707:_____/14:00431753!RIV15-AV0-68081707
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/14:00431753
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - inflammation; signaling; innate immunity (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Journal of Leukocyte Biology
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Perečko, Tomáš
- Dib, K.
- Jenei, V.
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1189/jlb.2AB0813-432RR
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