About: Dynamics of Polycomb chromatin domains under conditions of increased molecular crowding

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Background InformationA Polycomb (PcG) body is an orphan nuclear subcompartment characterised by accumulations of Polycomb repressive complex 1 (PRC1) proteins. However, seemingly contradictory reports have appeared that describe the PcG bodies either as protein-based bodies in the interchromatin compartment or chromatin domains. In this respect, molecular crowding is an important factor for the assembly and stability of nuclear subcompartments. In order to settle this contradiction, crowding experiments, that represent a convenient model distinguishing between interchromatin and chromatin compartments, were carried out. ResultsIn sucrose-hypertonically induced crowding, we observed in U-2 OS cells that PcG bodies disappeared, but persisted as nuclear domains characterised by accumulations of DNA. This phenomenon was also observed in cells hypertonically treated with sorbitol and NaCl. Background InformationA Polycomb (PcG) body is an orphan nuclear subcompartment characterised by accumulations of Polycomb repressive complex 1 (PRC1) proteins. However, seemingly contradictory reports have appeared that describe the PcG bodies either as protein-based bodies in the interchromatin compartment or chromatin domains. In this respect, molecular crowding is an important factor for the assembly and stability of nuclear subcompartments. In order to settle this contradiction, crowding experiments, that represent a convenient model distinguishing between interchromatin and chromatin compartments, were carried out. ResultsIn sucrose-hypertonically induced crowding, we observed in U-2 OS cells that PcG bodies disappeared, but persisted as nuclear domains characterised by accumulations of DNA. This phenomenon was also observed in cells hypertonically treated with sorbitol and NaCl. (en)
Title	Dynamics of Polycomb chromatin domains under conditions of increased molecular crowding Dynamics of Polycomb chromatin domains under conditions of increased molecular crowding (en)
skos:prefLabel	Dynamics of Polycomb chromatin domains under conditions of increased molecular crowding Dynamics of Polycomb chromatin domains under conditions of increased molecular crowding (en)
skos:notation	RIV/68081707:_____/13:00440589!RIV15-GA0-68081707
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(EE2.3.30.0030), P(GBP302/12/G157), S
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Bártová, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	70972
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/13:00440589
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Molecular crowding; Nuclear subcompartments; Polycomb body (en)
http://linked.open.../riv/klicoveSlovo	Polycomb body Molecular crowding Nuclear subcompartments
http://linked.open...odStatuVydavatele	FR - Francouzská republika
http://linked.open...ontrolniKodProRIV	[F015EFE4E352]
http://linked.open...i/riv/nazevZdroje	Biology of the Cell
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Dynamics and Organization of Chromosomes in the Cell Cycle and during Differentiation under Normal and Pathological Conditions Development of human resources in the field of cell biology
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	105
http://linked.open...iv/tvurceVysledku	Bártová, Eva Raška, I. Šmigová, J. Juda, P.
http://linked.open...ain/vavai/riv/wos	000330038400002
issn	0248-4900
number of pages	16 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/boc.201300022

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