About: DNA-damage response in chromatin of ribosomal genes and the surrounding genome

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About: DNA-damage response in chromatin of ribosomal genes and the surrounding genome Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	DNA repair events have functional significance especially for genome stability. Although the DNA damage response within the whole genome has been extensively studied, the region-specific characteristics of nuclear sub-compartments such as the nucleolus or fragile sites have not been fully elucidated. Here, we show that the heterochromatin protein HP1 and PML protein recognize spontaneously occurring 53BP1- or gamma-H2AX-positive DNA lesions throughout the genome. Moreover, 53BP1 nuclear bodies, which co-localize with PML bodies, also occur within the nucleoli compartments. Irradiation of the human osteosarcoma cell line U2OS with gamma-rays increases the degree of co-localization between 53BP1 and PML bodies throughout the genome; however, the 53BP1 protein is less abundant in chromatin of ribosomal genes and fragile sites (FRA3B and FRA16D) in gamma-irradiated cells. DNA repair events have functional significance especially for genome stability. Although the DNA damage response within the whole genome has been extensively studied, the region-specific characteristics of nuclear sub-compartments such as the nucleolus or fragile sites have not been fully elucidated. Here, we show that the heterochromatin protein HP1 and PML protein recognize spontaneously occurring 53BP1- or gamma-H2AX-positive DNA lesions throughout the genome. Moreover, 53BP1 nuclear bodies, which co-localize with PML bodies, also occur within the nucleoli compartments. Irradiation of the human osteosarcoma cell line U2OS with gamma-rays increases the degree of co-localization between 53BP1 and PML bodies throughout the genome; however, the 53BP1 protein is less abundant in chromatin of ribosomal genes and fragile sites (FRA3B and FRA16D) in gamma-irradiated cells. (en)
Title	DNA-damage response in chromatin of ribosomal genes and the surrounding genome DNA-damage response in chromatin of ribosomal genes and the surrounding genome (en)
skos:prefLabel	DNA-damage response in chromatin of ribosomal genes and the surrounding genome DNA-damage response in chromatin of ribosomal genes and the surrounding genome (en)
skos:notation	RIV/68081707:_____/13:00394805!RIV14-MSM-68081707
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GA13-07822S), P(GAP302/10/1022), P(GBP302/12/G157), P(LD11020), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Legartová, Soňa Bártová, Eva Hofer, Michal Kozubek, Stanislav Foltánková, Veronika
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	70158
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/13:00394805
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HISTONE H2AX; MULTIPLE-MYELOMA; LYSINE 56 (en)
http://linked.open.../riv/klicoveSlovo	HISTONE H2AX LYSINE 56 MULTIPLE-MYELOMA
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[EF4B3CD6B5E8]
http://linked.open...i/riv/nazevZdroje	Gene
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of epigenetic processes in DNA repair Dynamics and Organization of Chromosomes in the Cell Cycle and during Differentiation under Normal and Pathological Conditions Chromatin dynamics during DNA repair Epigenetics normal and tumor cells.
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	522
http://linked.open...iv/tvurceVysledku	Bártová, Eva Hofer, Michal Kozubek, Stanislav Legartová, Soňa Foltánková, Veronika
http://linked.open...ain/vavai/riv/wos	000320147000005
http://linked.open...n/vavai/riv/zamer	Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0378-1119
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.gene.2013.03.108

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