About: Arginine-Based Inhibitors of Nitric Oxide Synthase: Therapeutic Potential and Challenges

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In the past three decades, nitric oxide has been well established as an important bioactive molecule implicated in regulation of cardiovascular, nervous, and immune systems. Therefore, it is not surprising that much effort has been made to find specific inhibitors of nitric oxide synthases (NOS), the enzymes responsible for production of nitric oxide. Among the many NOS inhibitors developed to date, inhibitors based on derivatives and analogues of arginine are of special interest, as this category includes a relatively high number of compounds with good potential for experimental as well as clinical application. In the past three decades, nitric oxide has been well established as an important bioactive molecule implicated in regulation of cardiovascular, nervous, and immune systems. Therefore, it is not surprising that much effort has been made to find specific inhibitors of nitric oxide synthases (NOS), the enzymes responsible for production of nitric oxide. Among the many NOS inhibitors developed to date, inhibitors based on derivatives and analogues of arginine are of special interest, as this category includes a relatively high number of compounds with good potential for experimental as well as clinical application. (en)
Title	Arginine-Based Inhibitors of Nitric Oxide Synthase: Therapeutic Potential and Challenges Arginine-Based Inhibitors of Nitric Oxide Synthase: Therapeutic Potential and Challenges (en)
skos:prefLabel	Arginine-Based Inhibitors of Nitric Oxide Synthase: Therapeutic Potential and Challenges Arginine-Based Inhibitors of Nitric Oxide Synthase: Therapeutic Potential and Challenges (en)
skos:notation	RIV/68081707:_____/12:00390403!RIV13-AV0-68081707
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED1.100/02/0123), P(GA524/08/1753)
http://linked.open...iv/cisloPeriodika	2012
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Lojek, Antonín Kubala, Lukáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	123638
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/12:00390403
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	METHYL-L-ARGININE; HIGHLY SELECTIVE INHIBITORS; CARDIOVASCULAR RISK-FACTOR (en)
http://linked.open.../riv/klicoveSlovo	CARDIOVASCULAR RISK-FACTOR HIGHLY SELECTIVE INHIBITORS METHYL-L-ARGININE
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[D24FAD94C232]
http://linked.open...i/riv/nazevZdroje	Mediators of Inflammation
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	The influence of L-arginine and its analogues on the generation of reactive oxygen and nitrogen species by professional phagocytes St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	2012
http://linked.open...iv/tvurceVysledku	Kubala, Lukáš Lojek, Antonín Valacchi, G. Víteček, J.
http://linked.open...ain/vavai/riv/wos	000308758200001
issn	0962-9351
number of pages	22 (xsd:int)
http://bibframe.org/vocab/doi	10.1155/2012/318087

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