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Description
| - The effects of major DNA intrastrand cross-links of antitumor dinuclear Pt-II complexes [{trans-PtCl(NH3)(2)}(2)-mu-{trans-(H2N(CH2)(6)NH2(CH2)(2)NH2(CH2)(6) NH2)}](4+) (1) and [{PtCl(DACH)}(2)-mu-{H2N(CH2)(6)NH2 (CH2)(2)NH2(CH2)(6)NH2)}](4+) (2) (DACH is 1,2-diaminocyclohexane) on DNA stability were studied with emphasis on thermodynamic origins of that stability. Oligodeoxyribonucleotide duplexes containing the single 1,2, 1,3, or 1,5 intrastrand cross-links at guanine residues in the central TGGT, TGTGT, or TGTTTGT sequences, respectively, were prepared and analyzed by differential scanning calorimetry. The unfolding of the platinated duplexes was accompanied by unfavorable free energy terms.
- The effects of major DNA intrastrand cross-links of antitumor dinuclear Pt-II complexes [{trans-PtCl(NH3)(2)}(2)-mu-{trans-(H2N(CH2)(6)NH2(CH2)(2)NH2(CH2)(6) NH2)}](4+) (1) and [{PtCl(DACH)}(2)-mu-{H2N(CH2)(6)NH2 (CH2)(2)NH2(CH2)(6)NH2)}](4+) (2) (DACH is 1,2-diaminocyclohexane) on DNA stability were studied with emphasis on thermodynamic origins of that stability. Oligodeoxyribonucleotide duplexes containing the single 1,2, 1,3, or 1,5 intrastrand cross-links at guanine residues in the central TGGT, TGTGT, or TGTTTGT sequences, respectively, were prepared and analyzed by differential scanning calorimetry. The unfolding of the platinated duplexes was accompanied by unfavorable free energy terms. (en)
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Title
| - Thermodynamic stability and energetics of DNA duplexes containing major intrastrand cross-links of second-generation antitumor dinuclear Pt-II complexes
- Thermodynamic stability and energetics of DNA duplexes containing major intrastrand cross-links of second-generation antitumor dinuclear Pt-II complexes (en)
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skos:prefLabel
| - Thermodynamic stability and energetics of DNA duplexes containing major intrastrand cross-links of second-generation antitumor dinuclear Pt-II complexes
- Thermodynamic stability and energetics of DNA duplexes containing major intrastrand cross-links of second-generation antitumor dinuclear Pt-II complexes (en)
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skos:notation
| - RIV/68081707:_____/12:00389601!RIV13-AV0-68081707
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - I, P(GAP301/10/0598), P(GD301/09/H004), P(ME10066)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/12:00389601
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - NUCLEOTIDE EXCISION-REPAIR; PLATINUM ANTICANCER DRUGS; GROUP DOMAIN PROTEINS (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Journal of Biological Inorganic Chemistry
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Brabec, Viktor
- Kašpárková, Jana
- Farell, N. P.
- Florian, Jakub
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1007/s00775-011-0841-4
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