About: Bipyrimidine ruthenium(II) arene complexes: structure, reactivity and cytotoxicity

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About: Bipyrimidine ruthenium(II) arene complexes: structure, reactivity and cytotoxicity Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We have studied and contrasted the chemical reactivity of a series of organometallic RuII complexes of the type [(η6-arene)Ru(N,N’)X][PF6] containing an N,N chelating ligand, as well as various arenes, and different halildes (X). Calf thymus DNA interactions for [(η6-p-cym)Ru(bpm)Cl][PF6] and [(η6-p-cym)Ru(phen)Cl][PF6] (cym=para cymene, bpm=2,2-bipyrimidine, phen=1,10-phenanthroline) consist of weak coordinative, intercalative and monofunctional coordination. Binding to biomolecules such as glutatione may play a role in deactivating the bpm complexes. We have studied and contrasted the chemical reactivity of a series of organometallic RuII complexes of the type [(η6-arene)Ru(N,N’)X][PF6] containing an N,N chelating ligand, as well as various arenes, and different halildes (X). Calf thymus DNA interactions for [(η6-p-cym)Ru(bpm)Cl][PF6] and [(η6-p-cym)Ru(phen)Cl][PF6] (cym=para cymene, bpm=2,2-bipyrimidine, phen=1,10-phenanthroline) consist of weak coordinative, intercalative and monofunctional coordination. Binding to biomolecules such as glutatione may play a role in deactivating the bpm complexes. (en)
Title	Bipyrimidine ruthenium(II) arene complexes: structure, reactivity and cytotoxicity Bipyrimidine ruthenium(II) arene complexes: structure, reactivity and cytotoxicity (en)
skos:prefLabel	Bipyrimidine ruthenium(II) arene complexes: structure, reactivity and cytotoxicity Bipyrimidine ruthenium(II) arene complexes: structure, reactivity and cytotoxicity (en)
skos:notation	RIV/68081707:_____/12:00383620!RIV13-AV0-68081707
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP301/10/0598), P(GD301/09/H004), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Brabec, Viktor Nováková, Olga Lišková, Barbora
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	125210
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/12:00383620
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ruthenium(II) arene complexes; cytotoxicity; DNA binding (en)
http://linked.open.../riv/klicoveSlovo	cytotoxicity ruthenium(II) arene complexes DNA binding
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[7E39824825F8]
http://linked.open...i/riv/nazevZdroje	Journal of Biological Inorganic Chemistry
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular and structural biology of selected antitumor drugs. From mechanistic studies to chemotherapy of tumors Metallodrugs based on osmium, platinum and ruthenium complexes. From mechanistic studies to novel, more efficient chemotherapy of cancer
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	17
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Habtemariam, A. Sadler, P. J. Lišková, Barbora Nováková, Olga Betanzos-Lara, S. Clarkson, G. J. Deeth, R. J. Pizarro, A. M.
http://linked.open...ain/vavai/riv/wos	000308819200006
http://linked.open...n/vavai/riv/zamer	Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0949-8257
number of pages	19 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s00775-012-0917-9

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