About: Androgen depletion induces senescence in prostate cancer cells through down-regulation of Skp2

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Here we show that androgen deprivation therapy, a widely used treatment for advanced prostate cancer, induces senescence-associated secretory phenotype together with neuroendocrine differentiation in prostate cancer cells. The induction of senescent phenotype was at least in part mediated by down-regulation of Skp2, while neuroendocrine differentiation was under separate control. Induction of senescence may therefore contribute to development of androgen independence in response to androgen deprivation therapy. Here we show that androgen deprivation therapy, a widely used treatment for advanced prostate cancer, induces senescence-associated secretory phenotype together with neuroendocrine differentiation in prostate cancer cells. The induction of senescent phenotype was at least in part mediated by down-regulation of Skp2, while neuroendocrine differentiation was under separate control. Induction of senescence may therefore contribute to development of androgen independence in response to androgen deprivation therapy. (en)
Title	Androgen depletion induces senescence in prostate cancer cells through down-regulation of Skp2 Androgen depletion induces senescence in prostate cancer cells through down-regulation of Skp2 (en)
skos:prefLabel	Androgen depletion induces senescence in prostate cancer cells through down-regulation of Skp2 Androgen depletion induces senescence in prostate cancer cells through down-regulation of Skp2 (en)
skos:notation	RIV/68081707:_____/11:00391589!RIV13-MZ0-68081707
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(ED0030/01/01), P(GA310/07/0961), P(NS9600), P(NS9956), Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM0021622415), Z(MSM0021622430), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Slabáková, Eva Pernicová, Zuzana Kozubík, Alois Souček, Karel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	186250
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/11:00391589
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	prostate cancer; senescence; Skp2 (en)
http://linked.open.../riv/klicoveSlovo	Skp2 prostate cancer senescence
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[982298687999]
http://linked.open...i/riv/nazevZdroje	Neoplasia
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Biomedicine for regional development and human resources Possibilities in modulation of neuroendocrine differentiation and progression of prostate cancer. Significance of asporin and other extracellular matrix proteins in invasive carcinomas of breast and prostate The role of environmental pollutants in mechanisms regulating development of prostate carcinoma
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	13
http://linked.open...iv/tvurceVysledku	Bouchal, J. Kozubík, Alois Kharaishvili, G. Král, M. Kunická, Z. Machala, M. Pernicová, Zuzana Slabáková, Eva Souček, Karel
http://linked.open...ain/vavai/riv/wos	000295448800004
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Molecular basis of cell and tissue regulations Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies Modulation of signalling and regulatory pathways in normal and cancer cells
issn	1522-8002
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1593/neo.11182

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