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rdf:type
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Description
| - The 2-pyrrolinodoxorubicin shows 500-1000 times higher activity towards human and mouse cancer cells in vitro then parentel doxorubicin. We demonstrate that the blockade of DNA helicases by DNA adducts of p-DOX may be central in the mechanism of action of this anthracycline associated with its markedly enhanced activity as an anticancer drug.
- The 2-pyrrolinodoxorubicin shows 500-1000 times higher activity towards human and mouse cancer cells in vitro then parentel doxorubicin. We demonstrate that the blockade of DNA helicases by DNA adducts of p-DOX may be central in the mechanism of action of this anthracycline associated with its markedly enhanced activity as an anticancer drug. (en)
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Title
| - DNA interactions of 2-pyrrolinodoxorubicin, a distinctively more potent daunosamine-modified analogue of doxorubicin
- DNA interactions of 2-pyrrolinodoxorubicin, a distinctively more potent daunosamine-modified analogue of doxorubicin (en)
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skos:prefLabel
| - DNA interactions of 2-pyrrolinodoxorubicin, a distinctively more potent daunosamine-modified analogue of doxorubicin
- DNA interactions of 2-pyrrolinodoxorubicin, a distinctively more potent daunosamine-modified analogue of doxorubicin (en)
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skos:notation
| - RIV/68081707:_____/11:00375618!RIV12-AV0-68081707
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GD301/09/H004), Z(AV0Z40500505), Z(AV0Z50040507), Z(AV0Z50040702)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
| |
http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/11:00375618
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - doxorubicin; 2-pyrrolinodoxorubicin; DNA (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Brabec, Viktor
- Ulbrich, Karel
- Kašpárková, J.
- Lišková, Barbora
- Malina, Jaroslav
- Nováková, Olga
- Studenovský, Martin
- Štěpánková, Jana
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1016/j.bcp.2011.04.010
|