About: Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands

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About: Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The results of the present study showed that effects of model genotoxic and nongenotoxic AhR ligands on global changes in gene expression in LNCaP cells significantly overlap, thus suggesting that the activation of AhR plays a prominent role in the nongenotoxic effects of BaP in the prostate carcinoma cell model. We identified Wnt5a, an important regulator of prostate cancer progression, to be induced after exposure to both AhR ligands, which may further contribute to enhanced cell plasticity of prostate carcinoma cells. The results of the present study showed that effects of model genotoxic and nongenotoxic AhR ligands on global changes in gene expression in LNCaP cells significantly overlap, thus suggesting that the activation of AhR plays a prominent role in the nongenotoxic effects of BaP in the prostate carcinoma cell model. We identified Wnt5a, an important regulator of prostate cancer progression, to be induced after exposure to both AhR ligands, which may further contribute to enhanced cell plasticity of prostate carcinoma cells. (en)
Title	Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands (en)
skos:prefLabel	Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands (en)
skos:notation	RIV/68081707:_____/11:00368757!RIV12-AV0-68081707
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA310/07/0961), P(GA524/09/1337), S, Z(AV0Z50040507), Z(AV0Z50040702), Z(AV0Z50390512), Z(AV0Z50390703), Z(MSM0021622430), Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Vondráček, Jan Bryja, Vítězslav Souček, Karel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	200879
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/11:00368757
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	LNCaP cells; AhR ligands; WNT5A (en)
http://linked.open.../riv/klicoveSlovo	AhR ligands LNCaP cells WNT5A
http://linked.open...odStatuVydavatele	IE - Irsko
http://linked.open...ontrolniKodProRIV	[243919B901DF]
http://linked.open...i/riv/nazevZdroje	Toxicology Letters
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Interactions of Wnt and Ah receptor signaling in regulation of functions of liver cells The role of environmental pollutants in mechanisms regulating development of prostate carcinoma
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	206
http://linked.open...iv/tvurceVysledku	Bryja, Vítězslav Machala, M. Souček, Karel Topinka, Jan Vondráček, Jan Hrubá, E. Líbalová, Helena
http://linked.open...ain/vavai/riv/wos	000295298800010
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie New biotechnologies, nanomaterials and stem cells for use in regenerative medicine Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies Animal disease research, prevention and food chain protection
issn	0378-4274
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.toxlet.2011.07.011

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