About: Toxic Effects of Methylated Benzo[a]pyrenes in Rat Liver Stem-Like Cells

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	AhR-mediated activity of five selected MeBaP isomers was estimated in the DR-CALUX reporter gene assay performed in rat hepatoma cells. We identified 1-MeBaP as the most potent inducer of AhR activation, stable DNA adduct formation, checkpoint kinase 1 and p53 phosphorylation, and apoptosis. These effects suggest that 1-MeBaP is a potent genotoxin eliciting a typical sequence of events ascribed to carcinogenic PAHs. Importantly, 1-MeBaP and 3-MeBaP were found to be potent AhR agonists, 1 order of magnitude more potent than BaP, thus suggesting that the AhR-dependent modulations of gene expression, deregulation of cell survival mechanisms, and further nongenotoxic effects associated with AhR activation may further contribute to their tumor promotion and carcinogenicity. AhR-mediated activity of five selected MeBaP isomers was estimated in the DR-CALUX reporter gene assay performed in rat hepatoma cells. We identified 1-MeBaP as the most potent inducer of AhR activation, stable DNA adduct formation, checkpoint kinase 1 and p53 phosphorylation, and apoptosis. These effects suggest that 1-MeBaP is a potent genotoxin eliciting a typical sequence of events ascribed to carcinogenic PAHs. Importantly, 1-MeBaP and 3-MeBaP were found to be potent AhR agonists, 1 order of magnitude more potent than BaP, thus suggesting that the AhR-dependent modulations of gene expression, deregulation of cell survival mechanisms, and further nongenotoxic effects associated with AhR activation may further contribute to their tumor promotion and carcinogenicity. (en)
Title	Toxic Effects of Methylated Benzo[a]pyrenes in Rat Liver Stem-Like Cells Toxic Effects of Methylated Benzo[a]pyrenes in Rat Liver Stem-Like Cells (en)
skos:prefLabel	Toxic Effects of Methylated Benzo[a]pyrenes in Rat Liver Stem-Like Cells Toxic Effects of Methylated Benzo[a]pyrenes in Rat Liver Stem-Like Cells (en)
skos:notation	RIV/68081707:_____/11:00365862!RIV12-AV0-68081707
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA525/08/1590), Z(AV0Z50040702), Z(AV0Z50390512), Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Vondráček, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	235646
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/11:00365862
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Ah receptor; DNA adducts; WB F344 cells (en)
http://linked.open.../riv/klicoveSlovo	Ah receptor WB F344 cells DNA adducts
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[20D58962D718]
http://linked.open...i/riv/nazevZdroje	Chemical Research in Toxicology
http://linked.open...in/vavai/riv/obor	DN
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	13 (xsd:int)
http://linked.open...vavai/riv/projekt	Identification of endocrine disrupters, genotoxins and tumor promoters in abiotic matrixes of urban and agricultural environment
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	24
http://linked.open...iv/tvurceVysledku	Ciganek, M. Krčmář, P. Machala, M. Marvanová, S. Milcová, Alena Neča, J. Pěnčíková, K. Topinka, Jan Vondráček, Jan Trilecová, L. Hulínková, P. Krčková, S. Pálková, L.
http://linked.open...ain/vavai/riv/wos	000291896700011
http://linked.open...n/vavai/riv/zamer	Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie Animal disease research, prevention and food chain protection
issn	0893-228X
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1021/tx200049x

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