About: Conformation and recognition of DNA modified by a new antitumor dinuclear PtII complex resistant to decomposition by sulfur nucleophiles

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About: Conformation and recognition of DNA modified by a new antitumor dinuclear PtII complex resistant to decomposition by sulfur nucleophiles Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A detailed biochemical and molecular biophysics study of the molecular mechanism of action of a new dinuclear PtII complex [{PtCl(1,2-diaminocyclohexane)}2-my-Y]4+, resistant to decomposition by sulfur nucleophiles, was reported herein. The results show that this complex exhibits promising antitumor features as its DNA adducts can largely escape repair and inhibit very effectively transcription. A detailed biochemical and molecular biophysics study of the molecular mechanism of action of a new dinuclear PtII complex [{PtCl(1,2-diaminocyclohexane)}2-my-Y]4+, resistant to decomposition by sulfur nucleophiles, was reported herein. The results show that this complex exhibits promising antitumor features as its DNA adducts can largely escape repair and inhibit very effectively transcription. (en)
Title	Conformation and recognition of DNA modified by a new antitumor dinuclear PtII complex resistant to decomposition by sulfur nucleophiles Conformation and recognition of DNA modified by a new antitumor dinuclear PtII complex resistant to decomposition by sulfur nucleophiles (en)
skos:prefLabel	Conformation and recognition of DNA modified by a new antitumor dinuclear PtII complex resistant to decomposition by sulfur nucleophiles Conformation and recognition of DNA modified by a new antitumor dinuclear PtII complex resistant to decomposition by sulfur nucleophiles (en)
skos:notation	RIV/68081707:_____/10:00373396!RIV12-AV0-68081707
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS500040581), P(GD301/09/H004), P(KAN200200651), P(LC06030), P(ME08017), P(OC08003), P(OC09018), Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Brabec, Viktor Zerzánková, Lenka Vrána, Oldřich
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	251846
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/10:00373396
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	antitumor; dinuclear platinum complex; DNA damage (en)
http://linked.open.../riv/klicoveSlovo	DNA damage antitumor dinuclear platinum complex
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[199E3A245B62]
http://linked.open...i/riv/nazevZdroje	Biochemical Pharmacology
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Metallodrugs, design and mechansim of action Platinum Metal Complexes as DNA-Protein Cross-Linking Agents Structure, recognition, and processing of DNA damage by metal-based compounds of biological significance Molecular and structural biology of selected antitumor drugs. From mechanistic studies to chemotherapy of tumors Nanoparticulate and supramolecular systems for targeted drug delivery Biomolecular centre Mechanism of antitumor activity of metallodrugs. DNA replication and repair of DNA damage
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	79
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Zerzánková, Lenka Farrell, N. P. Suchánková, T. Vrána, Oldřich
http://linked.open...ain/vavai/riv/wos	000273506900004
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0006-2952
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.bcp.2009.08.009

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