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rdf:type
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Description
| - The primary objective was to understand more deeply the molecular mechanism underlying different antitumor effects of dinuclear Pt-II complexes containing aromatic linkers of different length, ([cisPt( NH3)(2)Cl](2)(4,4'-methylenedianiline)}(2+) (1) and {[cis-Pt(NH3)(2)Cl](2)(alpha,alpha'-diamino-p-xylene)}(2+) (2). These complexes belong to a new generation of promising polynuclear platinum drugs resistant to decomposition by sulfur nucleophiles which hampers clinical use of bifunctional polynuclear trans Pt-II complexes hitherto tested.
- The primary objective was to understand more deeply the molecular mechanism underlying different antitumor effects of dinuclear Pt-II complexes containing aromatic linkers of different length, ([cisPt( NH3)(2)Cl](2)(4,4'-methylenedianiline)}(2+) (1) and {[cis-Pt(NH3)(2)Cl](2)(alpha,alpha'-diamino-p-xylene)}(2+) (2). These complexes belong to a new generation of promising polynuclear platinum drugs resistant to decomposition by sulfur nucleophiles which hampers clinical use of bifunctional polynuclear trans Pt-II complexes hitherto tested. (en)
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Title
| - Mechanistic insights into antitumor effects of new dinuclear cis PtII complexes containing aromatic linkers
- Mechanistic insights into antitumor effects of new dinuclear cis PtII complexes containing aromatic linkers (en)
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skos:prefLabel
| - Mechanistic insights into antitumor effects of new dinuclear cis PtII complexes containing aromatic linkers
- Mechanistic insights into antitumor effects of new dinuclear cis PtII complexes containing aromatic linkers (en)
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skos:notation
| - RIV/68081707:_____/10:00373395!RIV12-AV0-68081707
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GAP301/10/0598), P(GD301/09/H004), P(IAA400040803), P(KAN200200651), P(LC06030), P(ME08017), P(ME10066), P(OC08003), P(OC09018), Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM6198959216)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/10:00373395
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - DNA; platinum; cancer (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Brabec, Viktor
- Kostrhunová, Hana
- Kašpárková, Jana
- Zerzánková, Lenka
- Nováková, Olga
- Vojtíšková, Marie
- Guo, Z.
- Suchánková, T.
- Lin, M.
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1016/j.bcp.2010.04.013
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