About: Studies on cellular accumulation of satraplatin and its major metabolite JM118 and their interactions with glutathione

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Studies on cellular accumulation of satraplatin and its major metabolite JM118 and their interactions with glutathione Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The organic cation transporters play a more important role in the mechanism of cytotoxicity of JM118 than in the cytotoxicity of cisplatin. Satraplatin is a poor substrate of these transporters. Satraplatin reacts with glutathione with the rate markedly lower than JM118 and cisplatin. Satraplatin can be activated by glutathione allowing it to react with DNA. The organic cation transporters play a more important role in the mechanism of cytotoxicity of JM118 than in the cytotoxicity of cisplatin. Satraplatin is a poor substrate of these transporters. Satraplatin reacts with glutathione with the rate markedly lower than JM118 and cisplatin. Satraplatin can be activated by glutathione allowing it to react with DNA. (en)
Title	Studies on cellular accumulation of satraplatin and its major metabolite JM118 and their interactions with glutathione Studies on cellular accumulation of satraplatin and its major metabolite JM118 and their interactions with glutathione (en)
skos:prefLabel	Studies on cellular accumulation of satraplatin and its major metabolite JM118 and their interactions with glutathione Studies on cellular accumulation of satraplatin and its major metabolite JM118 and their interactions with glutathione (en)
skos:notation	RIV/68081707:_____/10:00353777!RIV11-MSM-68081707
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP301/10/0598), P(IAA400040803), P(ME08017), P(ME10066), P(OC08003), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kostrhunová, Hana Brabec, Viktor Kašpárková, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	290639
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/10:00353777
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	JM118; cellular accumulation; glutathione (en)
http://linked.open.../riv/klicoveSlovo	cellular accumulation glutathione JM118
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[D70AE45FC365]
http://linked.open...i/riv/nazevZdroje	MOLECULAR PHARMACEUTICS
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Platinum Metal Complexes as DNA-Protein Cross-Linking Agents Structure, recognition, and processing of DNA damage by metal-based compounds of biological significance Metallodrugs based on osmium, platinum and ruthenium complexes. From mechanistic studies to novel, more efficient chemotherapy of cancer Mechanistic studies related to targeted cancer chemotherapy with light-activated platinum and ruthenium antitumor agents Transition metal-based anticancer compounds. From mechanistic studies to innovatory cancer chemotherapy
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Kostrhunová, Hana Kašpárková, Jana Gibson, D.
http://linked.open...ain/vavai/riv/wos	000284865900020
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	1543-8384
number of pages	10 (xsd:int)

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 82 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software