About: Selective binding of tumor suppressor p53 protein to topologically constrained DNA: Modulation by intercalative drugs

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About: Selective binding of tumor suppressor p53 protein to topologically constrained DNA: Modulation by intercalative drugs Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Selective binding of p53 to negatively and positively supercoiled DNA was studied using intercalative drugs chloroquine, ethidium bromide, acridine derivatives and doxorubicin as a modulators of the level of DNA supercoiling. The p53 was found to lose gradually its preferential binding to negatively scDNA with increasing concentrations of intercalators until the DNA negative superhelix turns were relaxed. Formation of positive superhelices rendered the circular duplex DNA to be preferentially bound by the p53 again. Selective binding of p53 to negatively and positively supercoiled DNA was studied using intercalative drugs chloroquine, ethidium bromide, acridine derivatives and doxorubicin as a modulators of the level of DNA supercoiling. The p53 was found to lose gradually its preferential binding to negatively scDNA with increasing concentrations of intercalators until the DNA negative superhelix turns were relaxed. Formation of positive superhelices rendered the circular duplex DNA to be preferentially bound by the p53 again. (en)
Title	Selective binding of tumor suppressor p53 protein to topologically constrained DNA: Modulation by intercalative drugs Selective binding of tumor suppressor p53 protein to topologically constrained DNA: Modulation by intercalative drugs (en)
skos:prefLabel	Selective binding of tumor suppressor p53 protein to topologically constrained DNA: Modulation by intercalative drugs Selective binding of tumor suppressor p53 protein to topologically constrained DNA: Modulation by intercalative drugs (en)
skos:notation	RIV/68081707:_____/10:00342523!RIV11-MSM-68081707
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS500040581), P(GA204/08/1560), P(GP204/07/P476), P(GP301/07/P160), P(IAA500040701), P(LC06035), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Pečinka, Petr Šebest, Peter Němcová, Kateřina Fojta, Miroslav Jagelská, Eva Brázda, Václav Pivoňková, Hana Tichá, Olga Brázdová, Marie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	286797
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/10:00342523
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	p53-DNA binding; supercoiled DNA; DNA topology (en)
http://linked.open.../riv/klicoveSlovo	DNA topology p53-DNA binding supercoiled DNA
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[DD1345454C64]
http://linked.open...i/riv/nazevZdroje	Biochemical and Biophysical Research Communications
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Metallodrugs, design and mechansim of action Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine. In vitro and in silico identification of non-canonical DNA structures in genomic DNA sequences Interactions of p73 protein and its isoforms with DNA. Influences of DNA supercoiling, conformation and anticancer drugs Study of posttranslation modification of the tumor suppressor protein p53, its homologues and interacting proteins in human cancer cell lines Interactions of wild type and mutant p53 proteins with damaged DNA and their roles in cellular response to anticancer chemotherapy
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	393
http://linked.open...iv/tvurceVysledku	Brázda, Václav Brázdová, Marie Fojta, Miroslav Pivoňková, Hana Tichá, Olga Němcová, Kateřina Pečinka, Petr Brázdová Jagelská, Eva Šebest, Peter
http://linked.open...ain/vavai/riv/wos	000276053800060
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0006-291X
number of pages	6 (xsd:int)

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