About: The potential of the cruciform structure formation as an important factor influencing p53 sequence-specific binding to natural DNA targets

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About: The potential of the cruciform structure formation as an important factor influencing p53 sequence-specific binding to natural DNA targets Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	P53 binding to DNA is strongly influenced by DNA topology. We investigated the cruciform structure formation of various inverted repeats in p53-responsive sequences from p21, RGC, mdm2 and GAAD45 promoters under negative superhelical stress and analyzed the effects of these DNA topology changes on p53-DNA binding. P53 binding to DNA is strongly influenced by DNA topology. We investigated the cruciform structure formation of various inverted repeats in p53-responsive sequences from p21, RGC, mdm2 and GAAD45 promoters under negative superhelical stress and analyzed the effects of these DNA topology changes on p53-DNA binding. (en)
Title	The potential of the cruciform structure formation as an important factor influencing p53 sequence-specific binding to natural DNA targets The potential of the cruciform structure formation as an important factor influencing p53 sequence-specific binding to natural DNA targets (en)
skos:prefLabel	The potential of the cruciform structure formation as an important factor influencing p53 sequence-specific binding to natural DNA targets The potential of the cruciform structure formation as an important factor influencing p53 sequence-specific binding to natural DNA targets (en)
skos:notation	RIV/68081707:_____/10:00340614!RIV10-AV0-68081707
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GP204/07/P476), P(GP301/07/P160), P(IAA500040701), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Fojta, Miroslav Jagelská, Eva Brázda, Václav Pivoňková, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	280476
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/10:00340614
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	scDNA; plasmid pBluescript SK; linear DNA (en)
http://linked.open.../riv/klicoveSlovo	linear DNA plasmid pBluescript SK scDNA
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[83CB32406888]
http://linked.open...i/riv/nazevZdroje	Biochemical and Biophysical Research Communications
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Interactions of p73 protein and its isoforms with DNA. Influences of DNA supercoiling, conformation and anticancer drugs Study of posttranslation modification of the tumor suppressor protein p53, its homologues and interacting proteins in human cancer cell lines Interactions of wild type and mutant p53 proteins with damaged DNA and their roles in cellular response to anticancer chemotherapy
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	391
http://linked.open...iv/tvurceVysledku	Brázda, Václav Fojta, Miroslav Pivoňková, Hana Brázdová Jagelská, Eva
http://linked.open...ain/vavai/riv/wos	000274097800021
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0006-291X
number of pages	6 (xsd:int)

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