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rdf:type
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Description
| - This study shows that phosphorylation of Bcl-2 can be induced by heavy metals due to activation of the Jun N-terminal kinase pathway that is not linked to the G2/M cell cycle arrest. Furthermore, we demonstrate that hyperphosphorylated Bcl-2 protein is a more potent inhibitor of zinc-induced cell death than its hypophosphorylated mutant form. These data suggest that regulation of Bcl-2 protein function by phosphorylation is an important part of cell responses to stress.
- This study shows that phosphorylation of Bcl-2 can be induced by heavy metals due to activation of the Jun N-terminal kinase pathway that is not linked to the G2/M cell cycle arrest. Furthermore, we demonstrate that hyperphosphorylated Bcl-2 protein is a more potent inhibitor of zinc-induced cell death than its hypophosphorylated mutant form. These data suggest that regulation of Bcl-2 protein function by phosphorylation is an important part of cell responses to stress. (en)
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Title
| - Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase
- Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase (en)
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skos:prefLabel
| - Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase
- Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase (en)
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skos:notation
| - RIV/68081707:_____/09:00345303!RIV11-GA0-68081707
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA204/07/0834), P(GA301/06/0036), P(IAA501630801), Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM0021622415)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/09:00345303
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Bcl-2; heavy metals; Jun N-terminal kinase (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Procházková, Jiřina
- Souček, Karel
- Šmarda, J.
- Beneš, P.
- Pelková, V.
- Ondroušková, E.
- Slováčková, J.
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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