About: Rottlerin inhibits ROS formation and prevents NFkappaB activation in MCF-7 and HT-29 cells

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About: Rottlerin inhibits ROS formation and prevents NFkappaB activation in MCF-7 and HT-29 cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Rottlerin, a polyphenol isolated from Mallotus Philippinensis, has been recently used as a selective inhibitor of PKC delta, although it can inhibit many kinases and has several biological effects. The current study confirms the antioxidant property of Rottlerin against the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) in vitro and against oxidative stress induced by H(2)O(2) and by menadione in culture cells. We also demonstrate that Rottlerin prevents TNFalpha-dependent NFkappaB activation in MCF-7 cells and in HT-29 cells transfected with the NFkappaB-driven plasmid pBIIX-LUC, suggesting that Rottlerin can inhibit NFkappaB via several pathways and in several cell types. Rottlerin, a polyphenol isolated from Mallotus Philippinensis, has been recently used as a selective inhibitor of PKC delta, although it can inhibit many kinases and has several biological effects. The current study confirms the antioxidant property of Rottlerin against the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) in vitro and against oxidative stress induced by H(2)O(2) and by menadione in culture cells. We also demonstrate that Rottlerin prevents TNFalpha-dependent NFkappaB activation in MCF-7 cells and in HT-29 cells transfected with the NFkappaB-driven plasmid pBIIX-LUC, suggesting that Rottlerin can inhibit NFkappaB via several pathways and in several cell types. (en)
Title	Rottlerin inhibits ROS formation and prevents NFkappaB activation in MCF-7 and HT-29 cells Rottlerin inhibits ROS formation and prevents NFkappaB activation in MCF-7 and HT-29 cells (en)
skos:prefLabel	Rottlerin inhibits ROS formation and prevents NFkappaB activation in MCF-7 and HT-29 cells Rottlerin inhibits ROS formation and prevents NFkappaB activation in MCF-7 and HT-29 cells (en)
skos:notation	RIV/68081707:_____/09:00340896!RIV10-AV0-68081707
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/07/0834), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Hýžďalová, Martina Souček, Karel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	339870
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/09:00340896
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Rottlerin; NFkappaB; HT-29 cells (en)
http://linked.open.../riv/klicoveSlovo	NFkappaB HT-29 cells Rottlerin
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[E559207E032A]
http://linked.open...i/riv/nazevZdroje	Journal of Biomedicine and Biotechnology
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Role of transforming growth factor-beta in regulation of proliferation, differentiation and apoptosis in prostate and colon cancer
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	-
http://linked.open...iv/tvurceVysledku	Souček, Karel Hýžďalová, Martina Valacchi, G. Maioli, E. Fortino, V. Greci, L. Pecorelli, A.
http://linked.open...ain/vavai/riv/wos	000274891700001
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	1110-7243
number of pages	7 (xsd:int)

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