About: Differences in TRAIL-induced changes of Mcl-1 expression among distinct human colon epithelial cell lines

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About: Differences in TRAIL-induced changes of Mcl-1 expression among distinct human colon epithelial cell lines Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We examined the changes of anti-apoptotic Mcl-1 protein level following TRAIL treatment in human epithelial cells representing different stages of colon carcinogenesis. While TRAIL was capable of triggering an anti-apoptotic signaling leading to significant early ERK-mediated transcriptional up-regulation of Mcl-1 in selected colon adenocarcinoma cell lines, none or very limited effects were demonstrated in cell lines derived from colon lymph node metastasis or fetal colon. We demonstrated an immediate impact of Mcl-1 protein level manipulations on the course of early acute apoptotic response of colon adenocarcinoma cells to TRAIL. We examined the changes of anti-apoptotic Mcl-1 protein level following TRAIL treatment in human epithelial cells representing different stages of colon carcinogenesis. While TRAIL was capable of triggering an anti-apoptotic signaling leading to significant early ERK-mediated transcriptional up-regulation of Mcl-1 in selected colon adenocarcinoma cell lines, none or very limited effects were demonstrated in cell lines derived from colon lymph node metastasis or fetal colon. We demonstrated an immediate impact of Mcl-1 protein level manipulations on the course of early acute apoptotic response of colon adenocarcinoma cells to TRAIL. (en)
Title	Differences in TRAIL-induced changes of Mcl-1 expression among distinct human colon epithelial cell lines Differences in TRAIL-induced changes of Mcl-1 expression among distinct human colon epithelial cell lines (en)
skos:prefLabel	Differences in TRAIL-induced changes of Mcl-1 expression among distinct human colon epithelial cell lines Differences in TRAIL-induced changes of Mcl-1 expression among distinct human colon epithelial cell lines (en)
skos:notation	RIV/68081707:_____/09:00335022!RIV10-AV0-68081707
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS500040507), P(GA301/07/1557), P(GA524/07/1178), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	19
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kozubík, Alois Hofmanová, Jiřina Vaculová, Alena Procházková, Jiřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	310467
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/09:00335022
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	TRAIL; Mcl-1; apoptosis (en)
http://linked.open.../riv/klicoveSlovo	Mcl-1 TRAIL apoptosis
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[ACDFA72D10F7]
http://linked.open...i/riv/nazevZdroje	Experimental Cell Research
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Lipid nutrition compounds - modulation of their effects and possibilities of practical application Novel anticancer platinum complexes - mechanisms of their action and innovative chemotherapy strategies Importance of cell lipid changes during differentiation and apoptosis of colon epithelial cells
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	315
http://linked.open...iv/tvurceVysledku	Hofmanová, Jiřina Kozubík, Alois Vaculová, Alena Zatloukalová, Jiřina
http://linked.open...ain/vavai/riv/wos	000271698000004
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0014-4827
number of pages	8 (xsd:int)

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