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rdf:type
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Description
| - We have examined activity of 12 Pt(II)-based DNA intercalators of the type [Pt(IL)(AL)]2+, where IL is an intercalating ligand (1,10-phenanthroline or a methylated derivative) and AL is an ancillary ligand (diaminocyclohexane, diphenylethylenediamine or 1,2-bis(4-fluorophenyl)-1,2-ethylenediamine) against a panel of human cancer cell lines and further in vitro testing was conducted to provide information about the mechanism of action.
- We have examined activity of 12 Pt(II)-based DNA intercalators of the type [Pt(IL)(AL)]2+, where IL is an intercalating ligand (1,10-phenanthroline or a methylated derivative) and AL is an ancillary ligand (diaminocyclohexane, diphenylethylenediamine or 1,2-bis(4-fluorophenyl)-1,2-ethylenediamine) against a panel of human cancer cell lines and further in vitro testing was conducted to provide information about the mechanism of action. (en)
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Title
| - Studies of the mechanism of action of platinum(II) complexes with potent cytotoxicity in human cancer cells
- Studies of the mechanism of action of platinum(II) complexes with potent cytotoxicity in human cancer cells (en)
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skos:prefLabel
| - Studies of the mechanism of action of platinum(II) complexes with potent cytotoxicity in human cancer cells
- Studies of the mechanism of action of platinum(II) complexes with potent cytotoxicity in human cancer cells (en)
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skos:notation
| - RIV/68081707:_____/09:00329490!RIV10-MSM-68081707
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(1QS500040581), P(IAA400040803), P(KAN200200651), P(LC06030), P(ME08017), P(OC08003), P(OC09018), Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM6198959216)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/09:00329490
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - platinum; metallointercalator; cytotoxicity (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Journal of Medicinal Chemistry
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Brabec, Viktor
- Kašpárková, Jana
- Malina, Jaroslav
- Bednarski, P. J.
- Grüner, R.
- Aldrich-Wright, J. R.
- Boag, L. R.
- Buczkowska, M.
- Fisher, D. M.
- Krause-Heuer, A. M.
- Kühne, S.
- Le Pevelen, D. D.
- Wheate, N. J.
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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