About: Monocytic differentiation of leukemic HL-60 cells induced by co-treatment with TNF-alpha and MK886 requires activation of pro-apoptotic machinery     Goto   Sponge   NotDistinct   Permalink

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  • Monocytic differentiation of leukemic HL-60 cells induced by co-treatment with TNF-alpha and MK886 is accompanied by activation of pro-apoptotic kinases p38 and JNK and caspases 8 and 9. Pharmacologic inhibition of those processes resulted in a decreased amount of differentiated cells, which illustrates the importance of those signaling pathways in monocytic differentiation of leukemic cells.
  • Monocytic differentiation of leukemic HL-60 cells induced by co-treatment with TNF-alpha and MK886 is accompanied by activation of pro-apoptotic kinases p38 and JNK and caspases 8 and 9. Pharmacologic inhibition of those processes resulted in a decreased amount of differentiated cells, which illustrates the importance of those signaling pathways in monocytic differentiation of leukemic cells. (en)
Title
  • Monocytic differentiation of leukemic HL-60 cells induced by co-treatment with TNF-alpha and MK886 requires activation of pro-apoptotic machinery
  • Monocytic differentiation of leukemic HL-60 cells induced by co-treatment with TNF-alpha and MK886 requires activation of pro-apoptotic machinery (en)
skos:prefLabel
  • Monocytic differentiation of leukemic HL-60 cells induced by co-treatment with TNF-alpha and MK886 requires activation of pro-apoptotic machinery
  • Monocytic differentiation of leukemic HL-60 cells induced by co-treatment with TNF-alpha and MK886 requires activation of pro-apoptotic machinery (en)
skos:notation
  • RIV/68081707:_____/09:00327497!RIV10-AV0-68081707
http://linked.open...avai/riv/aktivita
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  • P(1QS500040507), P(GP524/06/P345), S, Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika
  • 1
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  • 327400
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  • RIV/68081707:_____/09:00327497
http://linked.open...riv/jazykVysledku
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  • caspases; MAPK; MK886 (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [7925E7200B22]
http://linked.open...i/riv/nazevZdroje
  • European Journal of Haematology
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  • 83
http://linked.open...iv/tvurceVysledku
  • Hofmanová, Jiřina
  • Kozubík, Alois
  • Procházková, Jiřina
  • Souček, Karel
  • Stixová, Lenka
http://linked.open...ain/vavai/riv/wos
  • 000266875000004
http://linked.open...n/vavai/riv/zamer
issn
  • 0902-4441
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