About: Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo

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About: Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Wnt5a je morfogen, který aktivuje dráhu Wnt/PCP a plní mnohé funkce v časném vývoji. V předkládané práci popisuje to, jak Wnt5a reguluje Wnt/PCP dráhu v dopaminergní linii a jak zásadním způsobem reguluje vývoj ventrálního středního mozku (VM) in vivo. wnt5a v tomto kontextu reguluje morfogenezi VM, dělení progenitorů dopaminergních neuronů a diferenciaci NR4A2-pozitivních prekurzorů. (cs) Wnt5a is a morphogen that activates the Wnt/planar cell polarity (PCP) pathway and serves multiple functions during development. We hereby report a Wnt5a regulation of Wnt/PCP signaling in the DA lineage and provide evidence for multiple functions of Wnt5a in the VM in vivo, including the regulation of VM morphogenesis, DA progenitor cell division, and differentiation of NR4A2+ DA precursors. Wnt5a is a morphogen that activates the Wnt/planar cell polarity (PCP) pathway and serves multiple functions during development. We hereby report a Wnt5a regulation of Wnt/PCP signaling in the DA lineage and provide evidence for multiple functions of Wnt5a in the VM in vivo, including the regulation of VM morphogenesis, DA progenitor cell division, and differentiation of NR4A2+ DA precursors. (en)
Title	Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo (en) Wnt5a reguluje morfogenezi středního mozku a vývoj dopaminergních neuronů A9-A10 in vivo (cs)
skos:prefLabel	Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo (en) Wnt5a reguluje morfogenezi středního mozku a vývoj dopaminergních neuronů A9-A10 in vivo (cs)
skos:notation	RIV/68081707:_____/08:00319862!RIV09-AV0-68081707
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Bryjová, Lenka Bryja, Vítězslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	405830
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/08:00319862
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Wnt5a deficient mouse; ventral midbrain; planar cell polarity (en)
http://linked.open.../riv/klicoveSlovo	Wnt5a deficient mouse planar cell polarity ventral midbrain
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[E50C5E85D576]
http://linked.open...i/riv/nazevZdroje	PLoS ONE
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	3
http://linked.open...iv/tvurceVysledku	Bryja, Vítězslav Bryjová, Lenka Arenas, E. Čajánek, L. Andersson, E. R. Hall, A. C. Minina, E. Prakash, N. Wurst, W. Yamaguchi, T. P.
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	1932-6203
number of pages	14 (xsd:int)

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