About: Interaction of dinuclear ruthenium(II) supramolecular cylinders with DNA: sequence-specific binding, unwinding, and photocleavage

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We explored DNA unwinding and sequence-specific binding properties, as well as DNA photonuclease activity of ruthenium(II) metallosupramolecular cylinder [Ru2L3]4+. We found that [Ru2L3]4+ unwinds negatively supercoiled plasmid DNA and exhibits binding preference to regular alternating purine-pyrimidine sequences in a similar way to the [Fe2L3]4+ analogue. [Ru2L3]4+ induces single-strand breaks on irradiation by visible and UVA light and cleaves DNa mainly at guanine residues. We explored DNA unwinding and sequence-specific binding properties, as well as DNA photonuclease activity of ruthenium(II) metallosupramolecular cylinder [Ru2L3]4+. We found that [Ru2L3]4+ unwinds negatively supercoiled plasmid DNA and exhibits binding preference to regular alternating purine-pyrimidine sequences in a similar way to the [Fe2L3]4+ analogue. [Ru2L3]4+ induces single-strand breaks on irradiation by visible and UVA light and cleaves DNa mainly at guanine residues. (en) Studovali jsme interakci dinukleárního Ru(II) supramolekulárního cylindru [Ru2L3]4+ s dvouřetězcovou DNA. Výsledky ukázaly, že [Ru2L3]4+ rozvíjí negativně nadšroubovicově zavinutou plasmidovou DNA a vykazuje vazebnou preferenci k pravidelně se střídajícím purin-pyrimidinovým sekvencím podobně jako jeho železný analog [Fe2L3]4+. Na rozdíl od [Fe2L3]4+ vykazuje [Ru2L3]41 schopnost způsobovat jednořetězcové zlomy v DNA po ozáření UVA i viditelným světlem. Ke štěpení DNA dochází především v místech guaninových bází. (cs)
Title	Interaction of dinuclear ruthenium(II) supramolecular cylinders with DNA: sequence-specific binding, unwinding, and photocleavage Interakce dvojjaderných Ru(II) supramolekulárních cylindrů s DNA. Sekvenčně specifická vazba, rozvíjení a fotoštěpení (cs) Interaction of dinuclear ruthenium(II) supramolecular cylinders with DNA: sequence-specific binding, unwinding, and photocleavage (en)
skos:prefLabel	Interaction of dinuclear ruthenium(II) supramolecular cylinders with DNA: sequence-specific binding, unwinding, and photocleavage Interakce dvojjaderných Ru(II) supramolekulárních cylindrů s DNA. Sekvenčně specifická vazba, rozvíjení a fotoštěpení (cs) Interaction of dinuclear ruthenium(II) supramolecular cylinders with DNA: sequence-specific binding, unwinding, and photocleavage (en)
skos:notation	RIV/68081707:_____/08:00318497!RIV09-MZ0-68081707
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS500040581), P(IAA400040803), P(KAN200200651), P(KJB400040601), P(LC06030), P(ME08017), P(NR8562), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Brabec, Viktor Malina, Jaroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	372806
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/08:00318497
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DNA unwinding and photocleavage; ruthenium; supramolecular chemistry (en)
http://linked.open.../riv/klicoveSlovo	supramolecular chemistry ruthenium DNA unwinding and photocleavage
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[9CE062DADC90]
http://linked.open...i/riv/nazevZdroje	Chemistry - A European Journal
http://linked.open...in/vavai/riv/obor	AQ
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Metallodrugs, design and mechansim of action Recognition of DNA modified by antitumor platinum and ruthenium complexes by zinc-finger proteins and topoisomerases Platinum Metal Complexes as DNA-Protein Cross-Linking Agents Nanoparticulate and supramolecular systems for targeted drug delivery Biomolecular centre Inhibition of telomerase by transition metal complexes. A new concept of antitumor drug design Mechanistic studies related to targeted cancer chemotherapy with light-activated platinum and ruthenium antitumor agents
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	14
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Malina, Jaroslav Hannon, M. J.
http://linked.open...ain/vavai/riv/wos	000261559400031
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0947-6539
number of pages	7 (xsd:int)

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