About: Guanine quadruplex formation by RNA/DNA hybrid analogs of Oxytricha telomere G4T4G4 fragment

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Pomocí CD spektroskopie, gelové elektroforézy a UV absorpční spektroskopie jsme studovali uspořádání tetraplexu u RNA/DNA analogů Oxytricha telomerního fragmentu G4T4G4, který tvoří velmi dobře známý basketový antiparalelní tetraplex. Provedli jsme substituce riboguaninů (g) za deoxyriboguaniny (G) v pozicích G1, G9, T4 a G12; tyto pozice tvoří terminální tetrády tetraplexu G4T4G4 a zaujímají syn, syn, anti, a anti geometrii. Ukazujeme, že substituce jednoho cukru může vést ke změně tetraplexové topologie. (cs) Using circular dichroism spectroscopy, gel electrophoresis, and ultraviolet absorption spectroscopy, we have studied quadruplex folding of RNA/DNA analogs of the Oxytricha telomere fragment, G4T4G4, which forms the well-known basket-type, antiparallel quadruplex. We have substituted riboguanines (g) for deoxyriboguanines (G) in the positions G1, G9, G4, and G12; these positions form the terminal tetrads of the G4T4G4 quadruplex and adopt syn, syn, anti, and anti glycosidic geometries, respectively. We show that substitution of a single sugar was able to change the quadruplex topology. Using circular dichroism spectroscopy, gel electrophoresis, and ultraviolet absorption spectroscopy, we have studied quadruplex folding of RNA/DNA analogs of the Oxytricha telomere fragment, G4T4G4, which forms the well-known basket-type, antiparallel quadruplex. We have substituted riboguanines (g) for deoxyriboguanines (G) in the positions G1, G9, G4, and G12; these positions form the terminal tetrads of the G4T4G4 quadruplex and adopt syn, syn, anti, and anti glycosidic geometries, respectively. We show that substitution of a single sugar was able to change the quadruplex topology. (en)
Title	Guanine quadruplex formation by RNA/DNA hybrid analogs of Oxytricha telomere G4T4G4 fragment Guanine quadruplex formation by RNA/DNA hybrid analogs of Oxytricha telomere G4T4G4 fragment (en) Tvorba guaninových tetraplexů u RNA/DNA analogů Oxytricha telomerního fragmentu G4T4G4 (cs)
skos:prefLabel	Guanine quadruplex formation by RNA/DNA hybrid analogs of Oxytricha telomere G4T4G4 fragment Guanine quadruplex formation by RNA/DNA hybrid analogs of Oxytricha telomere G4T4G4 fragment (en) Tvorba guaninových tetraplexů u RNA/DNA analogů Oxytricha telomerního fragmentu G4T4G4 (cs)
skos:notation	RIV/68081707:_____/08:00311863!RIV09-AV0-68081707
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/07/0057), P(IAA100040701), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Kypr, Jaroslav Vorlíčková, Michaela Kejnovská, Iva Motlová, Jitka Fialová, Markéta
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	369704
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/08:00311863
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	RNA/DNA hybrids; guanine quadruplex; circular dichroism spectroscopy (en)
http://linked.open.../riv/klicoveSlovo	guanine quadruplex circular dichroism spectroscopy RNA/DNA hybrids
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[07012456F9C9]
http://linked.open...i/riv/nazevZdroje	Biopolymers
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Biophysical Properties of Biologically and Medically Important Regions of Human DNA Tetraplexes in the human genome
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	89
http://linked.open...iv/tvurceVysledku	Kypr, Jaroslav Vorlíčková, Michaela Kejnovská, Iva Fialová, Markéta Vondrušková, Jitka
http://linked.open...ain/vavai/riv/wos	000258844600001
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0006-3525
number of pages	10 (xsd:int)

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