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rdf:type
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Description
| - Binding of p53 to any DNA increased with increasing negative superhelix density. The p53 target sequences possessing the inverted-repeat symmetry were shown to form cruciform structure in sufficiently negative scDNA. We show that formation of the cruciforms in DNA topoisomers at - > 0.05 correlates with the extra enhancement of p53-DNA binding.
- Binding of p53 to any DNA increased with increasing negative superhelix density. The p53 target sequences possessing the inverted-repeat symmetry were shown to form cruciform structure in sufficiently negative scDNA. We show that formation of the cruciforms in DNA topoisomers at - > 0.05 correlates with the extra enhancement of p53-DNA binding. (en)
- Vazba proteinu p53 na DNA se zlepšuje se zvyšováním negativní supergelikální hustoty DNA. Cílové sekvence proteinu p53 s inverzní repetitivní sekvencí vytváří v scDNA křížové struktury. Vytváření křížové struktury u DNA topoizomerů - > 0.05 koreluje s výrazným zvýšením vazby proteinu p53 k DNA. (cs)
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Title
| - DNA topology influences p53 sequence-specific DNA binding through structural transitions within the target sites
- Topologie DNA ovlivňuje sekvenčně specifickou vazbu proteinu p53 strukturálními změnami v cílové sekvenci (cs)
- DNA topology influences p53 sequence-specific DNA binding through structural transitions within the target sites (en)
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skos:prefLabel
| - DNA topology influences p53 sequence-specific DNA binding through structural transitions within the target sites
- Topologie DNA ovlivňuje sekvenčně specifickou vazbu proteinu p53 strukturálními změnami v cílové sekvenci (cs)
- DNA topology influences p53 sequence-specific DNA binding through structural transitions within the target sites (en)
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skos:notation
| - RIV/68081707:_____/08:00309774!RIV09-AV0-68081707
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA301/05/0416), P(GP301/07/P160), P(IAA500040513), P(IAA500040701), P(KJB500040502), S, Z(AV0Z50040507), Z(AV0Z50040702)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/08:00309774
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - p53 protein; DNA binding; protein-DNA complex (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Brázda, Václav
- Fojta, Miroslav
- Paleček, Emil
- Brázdová Jagelská, Eva
- Pečinka, P.
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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