About: Platinum(IV) complex LA-12 perturbes cell cycle and causes apoptosis in human colorectal carcinoma cell lines

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About: Platinum(IV) complex LA-12 perturbes cell cycle and causes apoptosis in human colorectal carcinoma cell lines Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Platinový komplex LA-12 měl u nádorové buněčné linie kolonu HCT116 výraznější vliv na snížení proliferace a viability než oxaliplatina. Způsoboval zástavu v G2/M fázi buněčného cyklu nezávisle na statutu proteinu p53. Nižší koncentrace vedly k programované buněčné smrti v G1 fázi buněčného cyklu, vyšší vyvolaly apoptózu fázově nespecificky. (cs) Platinum complex LA-12 expressed more pronounced effects on proliferation and viability in colon carcinoma cell line HCT116 than oxaliplatin. It caused arrest in G2/M phase of the cell cycle independently on status of p53 protein. Lower concentrations led to programmed cell death in G1 phase, whereas higher concentration caused apoptosis phase non-specifically. Platinum complex LA-12 expressed more pronounced effects on proliferation and viability in colon carcinoma cell line HCT116 than oxaliplatin. It caused arrest in G2/M phase of the cell cycle independently on status of p53 protein. Lower concentrations led to programmed cell death in G1 phase, whereas higher concentration caused apoptosis phase non-specifically. (en)
Title	Platinum(IV) complex LA-12 perturbes cell cycle and causes apoptosis in human colorectal carcinoma cell lines Platinum(IV) complex LA-12 perturbes cell cycle and causes apoptosis in human colorectal carcinoma cell lines (en) Čtyřmocný platinový komplex LA-12 ovlivňuje buněčný cyklus a způsobuje apoptózu u lidské nádorové linie HCT116 (cs)
skos:prefLabel	Platinum(IV) complex LA-12 perturbes cell cycle and causes apoptosis in human colorectal carcinoma cell lines Platinum(IV) complex LA-12 perturbes cell cycle and causes apoptosis in human colorectal carcinoma cell lines (en) Čtyřmocný platinový komplex LA-12 ovlivňuje buněčný cyklus a způsobuje apoptózu u lidské nádorové linie HCT116 (cs)
skos:notation	RIV/68081707:_____/08:00309179!RIV09-AV0-68081707
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS500040507), P(GA301/07/1557), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Kozubík, Alois Hofmanová, Jiřina Vaculová, Alena Souček, Karel Vondálová Blanářová, Olga
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	386833
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/08:00309179
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	platinum drugs; cell cycle; apoptosis (en)
http://linked.open.../riv/klicoveSlovo	apoptosis cell cycle platinum drugs
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[4A67D2EC2705]
http://linked.open...i/riv/nazevZdroje	Chemické listy
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Lipid nutrition compounds - modulation of their effects and possibilities of practical application Novel anticancer platinum complexes - mechanisms of their action and innovative chemotherapy strategies
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	102
http://linked.open...iv/tvurceVysledku	Hofmanová, Jiřina Kozubík, Alois Souček, Karel Vaculová, Alena Blanářová, Olga Sova, P.
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0009-2770
number of pages	2 (xsd:int)

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