About: Acquired genomic aberrations associated with methotrexate resistance vary with background genomic instability

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About: Acquired genomic aberrations associated with methotrexate resistance vary with background genomic instability Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Tumors vary widely in chromosomal level genome instability. To gain a better understanding of the underlying defects which foster specific types of aberrations, we investigated the response of cells of related genetic backgrounds to challenge with methotrexate. We studied mismatch repair deficient HCT116 cells, two derivatives also deficient in XRCC5 (HCT116Ku86+/-) or BLM (HCT116 BLM-/-), and mismatch repair competent HCT116+chr3 cells. Tumors vary widely in chromosomal level genome instability. To gain a better understanding of the underlying defects which foster specific types of aberrations, we investigated the response of cells of related genetic backgrounds to challenge with methotrexate. We studied mismatch repair deficient HCT116 cells, two derivatives also deficient in XRCC5 (HCT116Ku86+/-) or BLM (HCT116 BLM-/-), and mismatch repair competent HCT116+chr3 cells. (en) Nádorové buňky se mezi sebou výrazně odlišují v míře a příčině genomové nestability. V této studii jsme zjišťovali závislost typu chromozomálních aberací na příčině genomické nestability. Porovnávali jsme mezi sebou buňky HCT116 s následujícími poruchami: HCT116 Mlh1+/-, HCT116 Mlh1-/-, HCT116 Ku86+/-, HCT116 BLM-/-. (cs)
Title	Acquired genomic aberrations associated with methotrexate resistance vary with background genomic instability Aberace spojené s rezistancí k metotrexátu se liší v závislosti na příčině genomické nestability (cs) Acquired genomic aberrations associated with methotrexate resistance vary with background genomic instability (en)
skos:prefLabel	Acquired genomic aberrations associated with methotrexate resistance vary with background genomic instability Aberace spojené s rezistancí k metotrexátu se liší v závislosti na příčině genomické nestability (cs) Acquired genomic aberrations associated with methotrexate resistance vary with background genomic instability (en)
skos:notation	RIV/68081707:_____/08:00306588!RIV08-AV0-68081707
http://linked.open.../vavai/riv/strany	71;83
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Gajdušková, Pavla
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	354777
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/08:00306588
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	genomic instability; array comparative genomic hybridization; methotrexate (en)
http://linked.open.../riv/klicoveSlovo	array comparative genomic hybridization methotrexate genomic instability
http://linked.open...odStatuVydavatele	SE - Švédské království
http://linked.open...ontrolniKodProRIV	[1BF43F4023ED]
http://linked.open...i/riv/nazevZdroje	Genes Chromosomes & Cancer
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	47
http://linked.open...iv/tvurceVysledku	Gajdušková, Pavla Albertson, D. G. Baughman, J. Buffart, T. E. Fridlyand, J. Hermsen, M. A. Huey, B. Meijer, G. A. Roydasgupta, R. Snijders, A. M. Tokuyasu, T.
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	1045-2257
number of pages	13 (xsd:int)

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