About: Response of normal and colon cancer epithelial cells to TNF-family apoptotic inducers

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Comparing the response of normal (FHC) and cancer (HT-29) colon epithelial cells showed differences expecially in TRAIL-induced apoptosis. Unlike FHC cells, apoptosis in HT-29 cells was potentiated by combination of TRAIL with inhibitor of MEK/ERK pathway U01126. The main difference between cell lines studied was found in the induction of mitochondrial pathway, which confirms its importance for TRAIL-induced apoptosis. Comparing the response of normal (FHC) and cancer (HT-29) colon epithelial cells showed differences expecially in TRAIL-induced apoptosis. Unlike FHC cells, apoptosis in HT-29 cells was potentiated by combination of TRAIL with inhibitor of MEK/ERK pathway U01126. The main difference between cell lines studied was found in the induction of mitochondrial pathway, which confirms its importance for TRAIL-induced apoptosis. (en) Srovnání odpovědi normální (FHC) a nádorové (HT-29) linie epiteliálních buněk kolonu ukázalo rozdíly zejména v indukci apoptózy indukované TRAIL. U buněk HT-29 byla na rozdíl od buněk FHC apoptóza posílena kombinací TRAIL s inhibitorem signální dráhy MEK/ERK U0126. Hlavní rozdíl mezi oběma liniemi byl nalezen v indukci mitochondriální dráhy apoptózy, což potvrzuje její důležitost pro TRAIL indukovanou apoptózu. (cs)
Title	Response of normal and colon cancer epithelial cells to TNF-family apoptotic inducers Response of normal and colon cancer epithelial cells to TNF-family apoptotic inducers (en) Odpověď normálních a nádorových epiteliálních buněk kolonu na působení apoptických induktorů rodiny TNF (cs)
skos:prefLabel	Response of normal and colon cancer epithelial cells to TNF-family apoptotic inducers Response of normal and colon cancer epithelial cells to TNF-family apoptotic inducers (en) Odpověď normálních a nádorových epiteliálních buněk kolonu na působení apoptických induktorů rodiny TNF (cs)
skos:notation	RIV/68081707:_____/08:00305780!RIV08-AV0-68081707
http://linked.open.../vavai/riv/strany	567;573
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA524/07/1178), P(KJB500040508), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Kozubík, Alois Hofmanová, Jiřina Vaculová, Alena Hýžďalová, Martina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	392571
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/08:00305780
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	apoptosis; TNF-related apoptosis inducing ligand; TNF-alpha (en)
http://linked.open.../riv/klicoveSlovo	TNF-alpha apoptosis TNF-related apoptosis inducing ligand
http://linked.open...odStatuVydavatele	GR - Řecká republika
http://linked.open...ontrolniKodProRIV	[64388787D975]
http://linked.open...i/riv/nazevZdroje	Oncology Reports
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Importance of cell lipid changes during differentiation and apoptosis of colon epithelial cells Cell adhesion and anoikis of intestinal cells - the role of TNF family members, AA metabolism, and differentiation
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	19
http://linked.open...iv/tvurceVysledku	Hofmanová, Jiřina Kozubík, Alois Vaculová, Alena Hýžďalová, Martina
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	1021-335X
number of pages	7 (xsd:int)

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