About: Differentiation of human embryonic stem cells induces condensation of chromosome territories and formation of heterochromatin protein 1 foci

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About: Differentiation of human embryonic stem cells induces condensation of chromosome territories and formation of heterochromatin protein 1 foci Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Nuclear arrangement, in correlation with transcriptional activity, of 0ct4 and the c-myc gene was investigated in human embryonic stem cells (hESC) undergoing differentiation. Additionally, nuclear distribution of all subtypes of HP1 protein was studied in this experimental system. The structures responsible for hESC pluripotency were characterized by more de-condensed nuclear arrangement, while more conserved nuclear topography was found for structures responsible for cell cycle regulation and/or differentiation, such as the c-myc gene. Nuclear arrangement, in correlation with transcriptional activity, of 0ct4 and the c-myc gene was investigated in human embryonic stem cells (hESC) undergoing differentiation. Additionally, nuclear distribution of all subtypes of HP1 protein was studied in this experimental system. The structures responsible for hESC pluripotency were characterized by more de-condensed nuclear arrangement, while more conserved nuclear topography was found for structures responsible for cell cycle regulation and/or differentiation, such as the c-myc gene. (en) Korelace mezi jaderným uspořádáním a transkripční aktivitou Oct4 a c-myc genů byly studovány u lidských embryonálních kmenových buněk (hESC) stimulovaných k diferenciaci. Jaderná distribuce všech variant HP1 proteinu byla navíc testována v tomto experimentálním systému. Struktury zodpovědné za hESC pluripotentnost byly charakteristické větší mírou de-kondenzace, než struktury, takové jako je c-myc gen, zodpovědné za regulaci buněčného cyklu nebo indukci diferenciace. (cs)
Title	Differentiation of human embryonic stem cells induces condensation of chromosome territories and formation of heterochromatin protein 1 foci Differentiation of human embryonic stem cells induces condensation of chromosome territories and formation of heterochromatin protein 1 foci (en) Diferenciace lidských embryonálních kmenových buněk indukuje kondenzaci chromosomálních teritorií a tvorbu ohnisek HP+ proteinu (cs)
skos:prefLabel	Differentiation of human embryonic stem cells induces condensation of chromosome territories and formation of heterochromatin protein 1 foci Differentiation of human embryonic stem cells induces condensation of chromosome territories and formation of heterochromatin protein 1 foci (en) Diferenciace lidských embryonálních kmenových buněk indukuje kondenzaci chromosomálních teritorií a tvorbu ohnisek HP+ proteinu (cs)
skos:notation	RIV/68081707:_____/08:00305724!RIV08-AV0-68081707
http://linked.open.../vavai/riv/strany	1;9
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1P05OC084), P(1QS500040508), P(GA204/06/0978), P(IAA5004306), P(LC535), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Krejčí, Jana Bártová, Eva Kozubek, Stanislav Harničarová Horáková, Andrea
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	363575
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/08:00305724
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	differentiation; human embryonic stem cells; chromatin structure (en)
http://linked.open.../riv/klicoveSlovo	chromatin structure differentiation human embryonic stem cells
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[1A4948DD2438]
http://linked.open...i/riv/nazevZdroje	Differentiation
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Dynamic structure and function of the cell nucleus after irradiation Methylation of histone H3 as a prognostic marker of chronic myeloid leukemia remission Chromosome dynamics and organization during the cell cycle in normal and pathologic conditions Postranslational modifications of histones after cell treatment by inhibitors of histone deacetylases and during induction of cell differentiation Human genome structure
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	76
http://linked.open...iv/tvurceVysledku	Bártová, Eva Kozubek, Stanislav Kroupová, Jana Harničarová, Andrea
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0301-4681
number of pages	9 (xsd:int)

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