About: Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation

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About: Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Here we provide evidence that an auto/paracrine gamma-amino butyric acid (GABa) signaling via GABA(A) receptors negatively controls embryonic stem (ES) cell and peripheral neural crest stem (NCS) cell proliferation, preimplantation embryonic growth as well as proliferation in the boundary cap stem cell niche, resulting in an attenuation of neuronal progenies from this niche. GABA(A) receptor activation hyperpolarizes the membrane potential, increase cell volume and cause accumulation of stem cells in the cell cycle S-phase, thereby causing a rapid reduction in cell proliferation. Here we provide evidence that an auto/paracrine gamma-amino butyric acid (GABa) signaling via GABA(A) receptors negatively controls embryonic stem (ES) cell and peripheral neural crest stem (NCS) cell proliferation, preimplantation embryonic growth as well as proliferation in the boundary cap stem cell niche, resulting in an attenuation of neuronal progenies from this niche. GABA(A) receptor activation hyperpolarizes the membrane potential, increase cell volume and cause accumulation of stem cells in the cell cycle S-phase, thereby causing a rapid reduction in cell proliferation. (en) Práce poskytuje důkazy o tom, že kyselina gamma-amino máselná (GABA) negativně reguluje proliferaci embryonálních kmenových buněk a kmenových buněk neurální lišty, a růst preimplantačního embrya. Aktivace GABa-A receptoru hyperpolarizuje membránový potenciál, zvyšuje buněčný objem a způsobuje akumulaci kmenových buněk v S fázi. (cs)
Title	Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation (en) Regulace proliferace kmenových buněk závislá na histonu H2AX a receptoru pro GABA(A) (cs)
skos:prefLabel	Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation (en) Regulace proliferace kmenových buněk závislá na histonu H2AX a receptoru pro GABA(A) (cs)
skos:notation	RIV/68081707:_____/08:00305700!RIV08-AV0-68081707
http://linked.open.../vavai/riv/strany	460;464
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	7177
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Bryja, Vítězslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	370169
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/08:00305700
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	GABA; stem cells; H2AX (en)
http://linked.open.../riv/klicoveSlovo	H2AX GABA stem cells
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[A5D6DC338C75]
http://linked.open...i/riv/nazevZdroje	Nature
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	17 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	451
http://linked.open...iv/tvurceVysledku	Bryja, Vítězslav Arenas, E. Castelo-Branco, G. Andäng, M. Charnay, P. El Manira, A. Ernfors, P. Halliez, S. Hjerling-Leffler, J. Ibanez, C. F. Koltzenburg, M. Lundgren, K. Moliner, A. Nanou, E. Nishimaru, H. Pozas, E. Wilbertz, J.
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0028-0836
number of pages	5 (xsd:int)

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