About: A potent cytotoxic photoactivated platinum complex

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Platinum(IV)diazido complexes containing cis-diam(m)ine ligands are relatively inert in the dark. We report here the dramatic effects arising from incorporation of a pyridine ligand in place of an ammine ligand. trans,trans,trans-[Pt(N3)2(OH)2(NH3)(py)] is highly phototoxic and reacts with guanine derivatives and with DNA to give unusual PtII adducts not readily formed in the absence of light. Platinum(IV)diazido complexes containing cis-diam(m)ine ligands are relatively inert in the dark. We report here the dramatic effects arising from incorporation of a pyridine ligand in place of an ammine ligand. trans,trans,trans-[Pt(N3)2(OH)2(NH3)(py)] is highly phototoxic and reacts with guanine derivatives and with DNA to give unusual PtII adducts not readily formed in the absence of light. (en)
Title	A potent cytotoxic photoactivated platinum complex A potent cytotoxic photoactivated platinum complex (en)
skos:prefLabel	A potent cytotoxic photoactivated platinum complex A potent cytotoxic photoactivated platinum complex (en)
skos:notation	RIV/68081707:_____/07:00345270!RIV11-GA0-68081707
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS500040581), P(GA305/05/2030), P(GD204/03/H016), P(NR8562), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	52
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Brabec, Viktor Kašpárková, Jana Heringová, Pavla
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	408108
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/07:00345270
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cytotoxicity; DNA binding; photochemistry (en)
http://linked.open.../riv/klicoveSlovo	cytotoxicity photochemistry DNA binding
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[E2474D1E1136]
http://linked.open...i/riv/nazevZdroje	Proceedings of the National Academy of Sciences of the United States of America
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Metallodrugs, design and mechansim of action New approaches to cancer chemotherapy by metal-based drugs Structural biophysics of macromolecules Inhibition of telomerase by transition metal complexes. A new concept of antitumor drug design
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	104
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Kašpárková, Jana Sadler, P. J. Pizarro, A. M. Heringová, Pavla Parsons, S. Mackay, F. S. Moggach, S. A. Woods, J. A
http://linked.open...ain/vavai/riv/wos	000252077400024
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0027-8424
number of pages	6 (xsd:int)

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