About: Biochemical studies of the thermal effects on DNA modifications by the antitumor cisplatin and their repair

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About: Biochemical studies of the thermal effects on DNA modifications by the antitumor cisplatin and their repair Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Using biochemical methods, the effect of two factors that might play a role in the mechanism of the biological activity of cisplatin at elevated temperatures (<37oC) have been examined. It has been shown that increased temperatures result in distinct alterations in the modification of the target DNA by cisplatin, and in the repair of these modifications. In vitro results support the view that the enhanced DNA-cross-linking efficiency of cisplatin and the lower efficiency of native DNA repair mechanisms at higher temperature play at least a partial role in the potentiation of the antitumor effects of cisplatin under conditions of mild hyperthermia. Using biochemical methods, the effect of two factors that might play a role in the mechanism of the biological activity of cisplatin at elevated temperatures (<37oC) have been examined. It has been shown that increased temperatures result in distinct alterations in the modification of the target DNA by cisplatin, and in the repair of these modifications. In vitro results support the view that the enhanced DNA-cross-linking efficiency of cisplatin and the lower efficiency of native DNA repair mechanisms at higher temperature play at least a partial role in the potentiation of the antitumor effects of cisplatin under conditions of mild hyperthermia. (en) Pomocí biochemických metod byl zkoumán vliv dvou faktorů, které mohou hrát roli v mechanismu biologické aktivity cisplatiny při zvýšených teplotách (<37oC). Bylo ukázáno, že zvýšené teploty mají za následek výrazné změny v modifikaci DNA cisplatinou a opravě těchto modifikací. Výsledky studií provedených in vitro podporují názor, podle kterého zvýšená účinnost vytvářet v DNA můstky a snížená účinnost mechanismů opravy DNA při zvýšených teplotách hraje přinejmenším částečnou roli v zesílení protinádorových efektů cisplatiny za podmínek mírné hypertermie. (cs)
Title	Biochemical studies of the thermal effects on DNA modifications by the antitumor cisplatin and their repair Biochemické studie vlivu tepla na modifikace DNA protinádorově účinnou cisplatinou a jejich opravu (cs) Biochemical studies of the thermal effects on DNA modifications by the antitumor cisplatin and their repair (en)
skos:prefLabel	Biochemical studies of the thermal effects on DNA modifications by the antitumor cisplatin and their repair Biochemické studie vlivu tepla na modifikace DNA protinádorově účinnou cisplatinou a jejich opravu (cs) Biochemical studies of the thermal effects on DNA modifications by the antitumor cisplatin and their repair (en)
skos:notation	RIV/68081707:_____/07:00092256!RIV08-AV0-68081707
http://linked.open.../vavai/riv/strany	2008;2015
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS500040581), P(GA203/05/2032), P(GA305/05/2030), P(GD204/03/H016), P(KAN200200651), P(LC06030), P(NR8562), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	16
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Brabec, Viktor Kašpárková, Jana Kisová-Halámiková, Anna Vrána, Oldřich
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	411786
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/07:00092256
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DNA; ruthenium; cancer (en)
http://linked.open.../riv/klicoveSlovo	DNA cancer ruthenium
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[E034946E992F]
http://linked.open...i/riv/nazevZdroje	Chembiochem
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Metallodrugs, design and mechansim of action New approaches to cancer chemotherapy by metal-based drugs Nanoparticulate and supramolecular systems for targeted drug delivery Biomolecular centre Structural biophysics of macromolecules Inhibition of telomerase by transition metal complexes. A new concept of antitumor drug design Raman spectroscopy of DNA modified by antitumor metal-based compounds
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	8
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Kašpárková, Jana Vrána, Oldřich Halámiková, Anna
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	1439-4227
number of pages	8 (xsd:int)

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