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rdf:type
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Description
| - The tethered RuII half-sandwich complexes [éta6:éta1-C6H5(CH2)nNH2)RuCl2] n=2 or 3 have been synthesized as potential bifunctional anticancer complexes, and their X-ray crystal structures have been determined. These complexes readily ruthenate calf thymus DNA so that only monofunctional DNA adducts are formel. These findings may explain why these complexes exhibit low cytotoxicities toward A2780 human ovarian cancer cells.
- The tethered RuII half-sandwich complexes [éta6:éta1-C6H5(CH2)nNH2)RuCl2] n=2 or 3 have been synthesized as potential bifunctional anticancer complexes, and their X-ray crystal structures have been determined. These complexes readily ruthenate calf thymus DNA so that only monofunctional DNA adducts are formel. These findings may explain why these complexes exhibit low cytotoxicities toward A2780 human ovarian cancer cells. (en)
- Arenové komplexy RuII [éta6:éta1-C6H5(CH2)nNH2)RuCl2] n=2 nebo 3 byly syntetizovány jako potenciální protinádorová léčiva. Byly také určeny jejich krystalografické struktury. Komplexy se váží na DNA, a to tak, že vytváří monofunkční adukty. Tyto výsledky mohou vysvětlit proč tyto komplexy vykazují pouze slabé cytotoxické efekty lidských ovariálních nádorových buňkách A2780. (cs)
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Title
| - Bifunctional amine-tethered ruthenium(II) arene complexes form monofunctional adducts on DNA
- Bifunctional amine-tethered ruthenium(II) arene complexes form monofunctional adducts on DNA (en)
- Bifunkční arenové komplexy Ru(II) s navázaným aminem vytvářejí na DNA monofunkční adukty (cs)
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skos:prefLabel
| - Bifunctional amine-tethered ruthenium(II) arene complexes form monofunctional adducts on DNA
- Bifunctional amine-tethered ruthenium(II) arene complexes form monofunctional adducts on DNA (en)
- Bifunkční arenové komplexy Ru(II) s navázaným aminem vytvářejí na DNA monofunkční adukty (cs)
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skos:notation
| - RIV/68081707:_____/07:00091784!RIV08-AV0-68081707
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(1QS500040581), P(GA203/06/1239), P(GA305/05/2030), P(KAN200200651), Z(AV0Z50040507), Z(AV0Z50040702)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/07:00091784
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - DNA; ruthenium; cancer (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Brabec, Viktor
- Habtemariam, A.
- Sadler, P. J.
- Nováková, Olga
- Parsons, S.
- Moggach, S. A.
- Fabbiani, F. P. A.
- Melchart, M.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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