About: Inhibitors of 5-lipoxygenase modulate the activity of mitogen activated protein kinases (MAPKs) and NF-kappaB in leukaemic HL-60

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About: Inhibitors of 5-lipoxygenase modulate the activity of mitogen activated protein kinases (MAPKs) and NF-kappaB in leukaemic HL-60 Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Treatment of leukaemic HL-60 cells by cytokine TNF-alpha and 5-lipoxygenase inhibitor MK-886 is accompanied with activation of pro-apoptotic MAPKs / (p38 and JNK), antiapoptotic MAPK (ERK) and also of pro-survival transcription factor NF-kappaB. Result implied that in monocytic differentiation induced by this treatment is inevitably involved the supression of pro-survival pathways. Treatment of leukaemic HL-60 cells by cytokine TNF-alpha and 5-lipoxygenase inhibitor MK-886 is accompanied with activation of pro-apoptotic MAPKs / (p38 and JNK), antiapoptotic MAPK (ERK) and also of pro-survival transcription factor NF-kappaB. Result implied that in monocytic differentiation induced by this treatment is inevitably involved the supression of pro-survival pathways. (en) Ovlivnění leukemických buněk HL-60 pomocí cytokinu TNF-alfa a inhibitoru 5-lipoxygenázy MK-886 je spojeno s aktivací pro-apoptotických MAPK (p38 a JNK), antiapoptotické MAPK (ERK) a transkripčního faktoru NF-kappaB, který podporuje přežití buněk. Z výsledků plyne, že pro takto indukovanou monocytární diferenciaci je nutné oslabení drah podporujících přežití studovaných buněk. (cs)
Title	Inhibitors of 5-lipoxygenase modulate the activity of mitogen activated protein kinases (MAPKs) and NF-kappaB in leukaemic HL-60 Inhibitors of 5-lipoxygenase modulate the activity of mitogen activated protein kinases (MAPKs) and NF-kappaB in leukaemic HL-60 (en) Inhibitory 5-lipoxygenázy ovlivňují aktivitu mitogenem aktivovaných kináz (MAPK) a NF-kappaB v leukemických buňkách HL-60 (cs)
skos:prefLabel	Inhibitors of 5-lipoxygenase modulate the activity of mitogen activated protein kinases (MAPKs) and NF-kappaB in leukaemic HL-60 Inhibitors of 5-lipoxygenase modulate the activity of mitogen activated protein kinases (MAPKs) and NF-kappaB in leukaemic HL-60 (en) Inhibitory 5-lipoxygenázy ovlivňují aktivitu mitogenem aktivovaných kináz (MAPK) a NF-kappaB v leukemických buňkách HL-60 (cs)
skos:notation	RIV/68081707:_____/07:00087269!RIV08-AV0-68081707
http://linked.open.../vavai/riv/strany	P50
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA524/05/0595), P(GP524/06/P345), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Kozubík, Alois Procházková, Jiřina Hofmanová, Jiřina Souček, Karel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	426671
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/07:00087269
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	MAPKs; TNF-alpha; NF-kappaB (en)
http://linked.open.../riv/klicoveSlovo	TNF-alpha NF-kappaB MAPKs
http://linked.open...odStatuVydavatele	PL - Polská republika
http://linked.open...ontrolniKodProRIV	[86804248CE7E]
http://linked.open...i/riv/nazevZdroje	Acta Biochimica Polonica
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Interactions of physiological growth regulators, arachidonic acid and xenobiotics Activity of inflammatory regulator NF-kappaB modulated by alteration of arachidonic acid metabolism
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	54
http://linked.open...iv/tvurceVysledku	Hofmanová, Jiřina Kozubík, Alois Procházková, Jiřina Souček, Karel Chlebová, K.
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0001-527X
number of pages	1 (xsd:int)

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