About: The role of ATM in chromosome end protection in Arabidopsis thaliana

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	ATM has an essential role in the DNA damage response. However, it is still unclear if ATM has a direct protective function specifically at telomeres. We addressed this question by FISH. We show that although chromosome fusions are induced by critically short telomeres, most of the anaphase bridges contain no telomeric of subtelomeric DNA signals, which strongly suggests that ATM protects short telomeres against an exonucleolytic attack. ATM has an essential role in the DNA damage response. However, it is still unclear if ATM has a direct protective function specifically at telomeres. We addressed this question by FISH. We show that although chromosome fusions are induced by critically short telomeres, most of the anaphase bridges contain no telomeric of subtelomeric DNA signals, which strongly suggests that ATM protects short telomeres against an exonucleolytic attack. (en) Ataxia telangiectasia mutated (ATM) hraje důležitou úlohu v odpovědi na poškození DNA. Je rovněž aktivní při údržbě telomer. Abychom zjistili, zda se ATM přímo účastní ochrany telomer, použili jsme FISH techniku pro mapování konců chromozómů mutantních rostlin (atm) Arabidopsis. Identifikovali jsme chromozómové fúze vzniklé následkem deprotekce telomer, což indikuje, že ATM chrání telomery před atakem exonukleáz. (cs)
Title	The role of ATM in chromosome end protection in Arabidopsis thaliana Úloha ATM v ochraně konců chromozómů u Arabidopsis thaliana (cs) The role of ATM in chromosome end protection in Arabidopsis thaliana (en)
skos:prefLabel	The role of ATM in chromosome end protection in Arabidopsis thaliana Úloha ATM v ochraně konců chromozómů u Arabidopsis thaliana (cs) The role of ATM in chromosome end protection in Arabidopsis thaliana (en)
skos:notation	RIV/68081707:_____/07:00087065!RIV08-AV0-68081707
http://linked.open.../vavai/riv/strany	51;52
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA522/06/0380), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	20
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Mokroš, Petr Široký, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	448170
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/07:00087065
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	telomeres; Arabidopsis; ATM protein kinase (en)
http://linked.open.../riv/klicoveSlovo	telomeres Arabidopsis ATM protein kinase
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[090490217F3B]
http://linked.open...i/riv/nazevZdroje	Chromosome Research
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	The study of genome instabilities in Arabidopsis mutants deficient for DNA repair and checkpoint proteins
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	15
http://linked.open...iv/tvurceVysledku	Široký, Jiří Mokroš, Petr Vespa, L. Shippen, D.
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0967-3849
number of pages	2 (xsd:int)

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