About: Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver %22stem-like%22 cells

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About: Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver %22stem-like%22 cells Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	TNF-alpha is known to play a major role in liver regeneration as well as in carcinogenesis. We investigated possible interaction of TNF-alpha with ligands of the AhR. TNF-alpha significantly potentiated proliferative effects of TCDD and PCB126 leading to an increased percentage of cells in S-phase of cell cycle and increased expression of cyclin A. TNF-alpha inhibited AhR-dependent induction of CYP1A1, in contrast, it enhanced induction of CYP1B1. TNF-alpha is known to play a major role in liver regeneration as well as in carcinogenesis. We investigated possible interaction of TNF-alpha with ligands of the AhR. TNF-alpha significantly potentiated proliferative effects of TCDD and PCB126 leading to an increased percentage of cells in S-phase of cell cycle and increased expression of cyclin A. TNF-alpha inhibited AhR-dependent induction of CYP1A1, in contrast, it enhanced induction of CYP1B1. (en) TNF-alfa hraje důležitou roli během procesu jaterní regenerace, stejně jako při vzniku karcinogeneze. V této práci se zabýváme možnou interakcí TNF-alfa s ligandy AhR. TNF-alfa významně posiluje proliferační účinky TCDD a PCB126, což vede ke zvýšení procenta buněk v S-fázi buněčného cyklu a zvýšenou expresi cyklinu A. TNF-alfa inhibuje AhR-dependentní indukci CYP1A1 a naopak posiluje expresi CYP1B1. (cs)
Title	Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver %22stem-like%22 cells Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver %22stem-like%22 cells (en) TNF-alfa se podílí na proliferaci a změně exprese enzymů cytochromu P450 indukovaných působením ligandů Ah receptoru u potkaních jaterních buněk (cs)
skos:prefLabel	Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver %22stem-like%22 cells Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver %22stem-like%22 cells (en) TNF-alfa se podílí na proliferaci a změně exprese enzymů cytochromu P450 indukovaných působením ligandů Ah receptoru u potkaních jaterních buněk (cs)
skos:notation	RIV/68081707:_____/07:00085551!RIV08-AV0-68081707
http://linked.open.../vavai/riv/strany	79;89
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA524/05/0595), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Umannová, Lenka Kozubík, Alois Vondráček, Jan Procházková, Jiřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	455972
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/07:00085551
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	tumor necrosis factor-alpha; xenobiotic metabolizing enzymes; dioxin (en)
http://linked.open.../riv/klicoveSlovo	tumor necrosis factor-alpha dioxin xenobiotic metabolizing enzymes
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[170141879844]
http://linked.open...i/riv/nazevZdroje	Toxicological Sciences
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Interactions of physiological growth regulators, arachidonic acid and xenobiotics
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	99
http://linked.open...iv/tvurceVysledku	Kozubík, Alois Krčmář, P. Machala, M. Umannová, Lenka Vondráček, Jan Zatloukalová, Jiřina Májková, Z. Hennig, B.
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0388-1350
number of pages	11 (xsd:int)

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