About: Dual triggering of DNA binding and fluorescence via photoactivation of a dinuclear ruthenium(II) arene complex

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About: Dual triggering of DNA binding and fluorescence via photoactivation of a dinuclear ruthenium(II) arene complex Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Byly syntetizovány a charakterizovány dvojjaderné arenové komplexy Ru99[{(n6-arene)RuCl}2(u-2,3-dpp)](PF6)2, arene = indan (1), benzen (2), p-cymen (3) nebo hexamethylbenzen (4) a 2,3-dpp = 2,3-bis(2-pyridyl)pyrazin. Po ozáření světlem UVA se z komplexů 1 a 2 odštěpily arenové skupiny, zatímco z komplexů 3 a 4 ne. Komplexy 1 a 2 mohou fotoaktivací vyvolávat smrt buněk a pomocí fluorescence lokalizovat a monitorovat účinnost fotoaktivačního děje. (cs) The dinuclear RuII arene complexes [{(n6-arene)RuCl}2(u-2,3-dp)](PF6)2, arene = indan (1), benzene (2), p-cymene (3), or hexamethylbenzene (4) and 2,3-dpp = 2,3-bis(2-pyridyl)pyrazine, have been synthesized and characterized. Upon irradiation with UVA light, complexes 1 and 2 readily underwent arene loss, while complexes 3 and 4 did not. The complexes 1 and 2 have the potential to combine both photoinduced cell death and fluorescence imaging of the location and efficiency of the photoactivation process. The dinuclear RuII arene complexes [{(n6-arene)RuCl}2(u-2,3-dp)](PF6)2, arene = indan (1), benzene (2), p-cymene (3), or hexamethylbenzene (4) and 2,3-dpp = 2,3-bis(2-pyridyl)pyrazine, have been synthesized and characterized. Upon irradiation with UVA light, complexes 1 and 2 readily underwent arene loss, while complexes 3 and 4 did not. The complexes 1 and 2 have the potential to combine both photoinduced cell death and fluorescence imaging of the location and efficiency of the photoactivation process. (en)
Title	Dual triggering of DNA binding and fluorescence via photoactivation of a dinuclear ruthenium(II) arene complex Vyvolání vazby k DNA a fluorescence fotoaktivací dvojjaderným arenovým komplexem ruthenia(II) (cs) Dual triggering of DNA binding and fluorescence via photoactivation of a dinuclear ruthenium(II) arene complex (en)
skos:prefLabel	Dual triggering of DNA binding and fluorescence via photoactivation of a dinuclear ruthenium(II) arene complex Vyvolání vazby k DNA a fluorescence fotoaktivací dvojjaderným arenovým komplexem ruthenia(II) (cs) Dual triggering of DNA binding and fluorescence via photoactivation of a dinuclear ruthenium(II) arene complex (en)
skos:notation	RIV/68081707:_____/07:00083868!RIV08-AV0-68081707
http://linked.open.../vavai/riv/strany	5059;5068
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS500040581), P(GA203/06/1239), P(GA305/05/2030), P(KAN200200651), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Brabec, Viktor Nováková, Olga
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	418228
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/07:00083868
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DNA; ruthenium; fluorescence (en)
http://linked.open.../riv/klicoveSlovo	DNA fluorescence ruthenium
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[1573A1597EB8]
http://linked.open...i/riv/nazevZdroje	Inorganic Chemistry
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Metallodrugs, design and mechansim of action New approaches to cancer chemotherapy by metal-based drugs Nanoparticulate and supramolecular systems for targeted drug delivery Tolerance and bypass of DNA damage by metal-based anticancer drugs
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	46
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Habtemariam, A. Sadler, P. J. Nováková, Olga Henry, J. B. Parsons, S. Magennis, S. W. Meier, S. Oswald, D. H.
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0020-1669
number of pages	10 (xsd:int)

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