About: Inhibition of endocytosis blocks Wnt signalling to beta-catenin by promoting dishevelled degradation     Goto   Sponge   NotDistinct   Permalink

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Description
  • Zkoumali jsme vliv inhibice endocytózy na lokalizaci proteinu Frizzled4 na hladinu proteinu Dishevelled a na signálování proteinu Wnt-3a. Inhibice endocytózy, ať už s využitím hyperosmolární sacharózy nebo deplece draslíkových iontů zvýšilo membránovou lokalizaci Frizzled4 a zároveň vyvolalo rychlou (1-2 h) a takřka kompletní (95%) degradaci endogenního Dishevelled, což v důsledku zabránilo přenosu signálu proteinu Wnt-3a k beta-cateninu. Tyto výsledky poskytují důkazy pro existenci molekulárního mechanismu, který může tvořit základ negativní zpětné vazby ve Wnt/Frizzled dráze, a který závisí na degradaci dishevelled. (cs)
  • We investigated the effects of endocytosis inhibition on Frizzled4-green fluorescent protein (FZD4-GFP) localization, dishevelled levels and Wnt-3a signalling to beta-catenin. Hyperosmotic sucrose and K+ depletion increased the membrane localization of FZD4-GFP, and in parallel triggered fast (1-2 h) and almost complete (approx. 95%) degradation of endogenous dishevelled, which further prevented canonical signalling by Wnt-3a to beta-catenin. The data provide evidence for a molecular mechanism that could be a basis for a novel negative feedback loop within the Wnt/Frizzled pathway depending on dishevelled degradation.
  • We investigated the effects of endocytosis inhibition on Frizzled4-green fluorescent protein (FZD4-GFP) localization, dishevelled levels and Wnt-3a signalling to beta-catenin. Hyperosmotic sucrose and K+ depletion increased the membrane localization of FZD4-GFP, and in parallel triggered fast (1-2 h) and almost complete (approx. 95%) degradation of endogenous dishevelled, which further prevented canonical signalling by Wnt-3a to beta-catenin. The data provide evidence for a molecular mechanism that could be a basis for a novel negative feedback loop within the Wnt/Frizzled pathway depending on dishevelled degradation. (en)
Title
  • Inhibition of endocytosis blocks Wnt signalling to beta-catenin by promoting dishevelled degradation
  • Inhibition of endocytosis blocks Wnt signalling to beta-catenin by promoting dishevelled degradation (en)
  • Inhibice endocytózy blokuje přenos signálu Wnt na beta-katenin posílením degradace Dishevelled (cs)
skos:prefLabel
  • Inhibition of endocytosis blocks Wnt signalling to beta-catenin by promoting dishevelled degradation
  • Inhibition of endocytosis blocks Wnt signalling to beta-catenin by promoting dishevelled degradation (en)
  • Inhibice endocytózy blokuje přenos signálu Wnt na beta-katenin posílením degradace Dishevelled (cs)
skos:notation
  • RIV/68081707:_____/07:00082914!RIV07-AV0-68081707
http://linked.open.../vavai/riv/strany
  • 53;596
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z50040507)
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 426665
http://linked.open...ai/riv/idVysledku
  • RIV/68081707:_____/07:00082914
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • beta-catenin; clathrin-mediated endocytosis; desensitization (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [CA2DB22CEFE5]
http://linked.open...i/riv/nazevZdroje
  • Acta physiologica Scandinavica
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 190
http://linked.open...iv/tvurceVysledku
  • Bryja, Vítězslav
  • Schulte, G.
  • Čajánek, L.
  • Grahn, A.
http://linked.open...n/vavai/riv/zamer
issn
  • 0001-6772
number of pages
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