About: Impact of an extruded nucleotide on cleavage activity and dynamic catalytic core conformation of the hepatitis delta virus ribozyme

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About: Impact of an extruded nucleotide on cleavage activity and dynamic catalytic core conformation of the hepatitis delta virus ribozyme Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Samoštěpení HDV ribozymu je esenciální pro replikaci HDV, lidského patogenu jater. Katalyticky důležitý nukleotid C75 je podporován uspořádáním do trojlístku kolem vytěsněného G76. Ve všech dostupných krystalových strukturách je konformace G76 omezená stackingem s G76 sousedící molekuly. Za účelem zjistit, jestli tento krystalový kontakt vnáší nebo nevnáší strukturní chybu do katalytického jádra, jsme analyzovali cca 200 ns molekulově dynamických simulací. (cs) The self-cleaving hepatitis delta virus (HDV) ribozyme is essential for the replication of HDV, a liver disease causing pathogen in humans. The catalytically critical nucleotide C75 of the ribozyme is buttressed by a trefoil turn pivoting around an extruded G76. In all available crystal structures, the conformation of G76 is restricted by stacking with G76 of a neighboring molecule. To test whether this crystal contact introduces a structural perturbation into a catalytic core, we have analyzed ~200 ns of molecular dynamics simulations. The self-cleaving hepatitis delta virus (HDV) ribozyme is essential for the replication of HDV, a liver disease causing pathogen in humans. The catalytically critical nucleotide C75 of the ribozyme is buttressed by a trefoil turn pivoting around an extruded G76. In all available crystal structures, the conformation of G76 is restricted by stacking with G76 of a neighboring molecule. To test whether this crystal contact introduces a structural perturbation into a catalytic core, we have analyzed ~200 ns of molecular dynamics simulations. (en)
Title	Impact of an extruded nucleotide on cleavage activity and dynamic catalytic core conformation of the hepatitis delta virus ribozyme Vliv vytěsněného nukleotidu na aktivitu štěpení a konformační dynamiku katalytického jádra hepatitis delta virus ribozymu (cs) Impact of an extruded nucleotide on cleavage activity and dynamic catalytic core conformation of the hepatitis delta virus ribozyme (en)
skos:prefLabel	Impact of an extruded nucleotide on cleavage activity and dynamic catalytic core conformation of the hepatitis delta virus ribozyme Vliv vytěsněného nukleotidu na aktivitu štěpení a konformační dynamiku katalytického jádra hepatitis delta virus ribozymu (cs) Impact of an extruded nucleotide on cleavage activity and dynamic catalytic core conformation of the hepatitis delta virus ribozyme (en)
skos:notation	RIV/68081707:_____/07:00081633!RIV07-AV0-68081707
http://linked.open.../vavai/riv/strany	392;406
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS500040581), P(GA203/05/0009), P(GA203/05/0388), P(LC512), Z(AV0Z50040507)
http://linked.open...iv/cisloPeriodika	5-6
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Krasovská, Maryna V. Šponer, Jiří Špačková, Naďa
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	425545
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/07:00081633
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	conformational dynamics; hepatitis delta virus; molecular dynamics (en)
http://linked.open.../riv/klicoveSlovo	molecular dynamics conformational dynamics hepatitis delta virus
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[1214AA483A7F]
http://linked.open...i/riv/nazevZdroje	Biopolymers
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Metallodrugs, design and mechansim of action Center for biomolecules and complex molecular systems Structure and dynamics of DNA nitrogeneous bases, base pairs, oligonucleotides and their complexes with water, ions and drugs Conformational dynamics of nucleic acids
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	85
http://linked.open...iv/tvurceVysledku	Šponer, Jiří Walter, N. G. Špačková, Naděžda Krasovská, Maryna V. Šefčíková, J.
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems
issn	0006-3525
number of pages	15 (xsd:int)

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