About: Dibenzanthracenes and benzochrysenes elicit both genotoxic and nongenotoxic events in rat liver 'stem-like' cells

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About: Dibenzanthracenes and benzochrysenes elicit both genotoxic and nongenotoxic events in rat liver 'stem-like' cells Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	V této studii popisujeme, že dibenzanthraceny a benzochryseny, s výjimkou BgChry, působí v jaterních epiteliálních buňkách především prostřednictvím deregulace buněčné proliferace, což souvisí s jejich relativně vysokou aktivitou zprostředkovanou AhR. Narušení kontroly buněčného cyklu může přispívat k jejich karcinogenním účinkům, i ke karcinogenitě složitých environmentálních směsí, které obsahují vysoké hladiny PAU s molekulovou váhou 278. (cs) In the present study we describe that dibenzanthracenes and benzochrysenes, with exception of BgChry, seem to act primarily through deregulation of cell proliferation in liver epithelial cells, which is related to their relatively high ahR-mediated activity. The disruption of cell cycle control might contribute to their carcinogenic effects, as well as to carcinogenicity of complex environmental mixtures containing high levels of PAHs with molecular weight 278. In the present study we describe that dibenzanthracenes and benzochrysenes, with exception of BgChry, seem to act primarily through deregulation of cell proliferation in liver epithelial cells, which is related to their relatively high ahR-mediated activity. The disruption of cell cycle control might contribute to their carcinogenic effects, as well as to carcinogenicity of complex environmental mixtures containing high levels of PAHs with molecular weight 278. (en)
Title	Dibenzanthracenes and benzochrysenes elicit both genotoxic and nongenotoxic events in rat liver 'stem-like' cells Dibenzanthracenes and benzochrysenes elicit both genotoxic and nongenotoxic events in rat liver 'stem-like' cells (en) Dibenzanthraceny a benzochryseny způsobují jak genotoxické, tak negenotoxické účinky v jaterních progenitorových buňkách potkana (cs)
skos:prefLabel	Dibenzanthracenes and benzochrysenes elicit both genotoxic and nongenotoxic events in rat liver 'stem-like' cells Dibenzanthracenes and benzochrysenes elicit both genotoxic and nongenotoxic events in rat liver 'stem-like' cells (en) Dibenzanthraceny a benzochryseny způsobují jak genotoxické, tak negenotoxické účinky v jaterních progenitorových buňkách potkana (cs)
skos:notation	RIV/68081707:_____/07:00081063!RIV07-MZP-68081707
http://linked.open.../vavai/riv/strany	147;159
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(SL/5/160/05)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Kozubík, Alois Vondráček, Jan Švihálková-Šindler, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	417080
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/07:00081063
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	aryl hydrocarbon receptor; DNA adducts; cytochromes P450 (en)
http://linked.open.../riv/klicoveSlovo	aryl hydrocarbon receptor DNA adducts cytochromes P450
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[7AECEB7779A4]
http://linked.open...i/riv/nazevZdroje	Biochemical Pharmacology
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Environmental factors and health
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	232
http://linked.open...iv/tvurceVysledku	Kozubík, Alois Topinka, Jan Vondráček, Jan Machala, Miroslav Neča, Jiří Pěnčíková, Kateřina Marvanová, Soňa Sevastyanova, Oksana Šindlerová, Lenka
issn	0006-2952
number of pages	13 (xsd:int)

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