About: NMR analysis of duplex d(CGCGATCGCG)2 modified by lambda- and delta-[Ru(bpy)2(m-GHK)]Cl2 and DNA photocleavage study

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About: NMR analysis of duplex d(CGCGATCGCG)2 modified by lambda- and delta-[Ru(bpy)2(m-GHK)]Cl2 and DNA photocleavage study Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The interaction of the diastereomeric complexes delta-[Ru(bpy)2(m-GHK)]Cl2 and lambda-[Ru(bpy)2(m-GHK)]Cl2 (bpy is 2,2'-bipyridine, GHK is glycine-1-histidine-1-lysine) with the deoxyribonucleotide duplex d(5'-CGCGATCGCG)2 was characterized by means of 1H NMR spectroscopy. In addition, photocleavage studies were also conducted with the plasmid pUC19 and a 158-bp restriction fragment, showing that both diastereomers cleave DNA with similar efficiency, attacking mainly the guanines of the sequence probably by generating active oxygen species. The interaction of the diastereomeric complexes delta-[Ru(bpy)2(m-GHK)]Cl2 and lambda-[Ru(bpy)2(m-GHK)]Cl2 (bpy is 2,2'-bipyridine, GHK is glycine-1-histidine-1-lysine) with the deoxyribonucleotide duplex d(5'-CGCGATCGCG)2 was characterized by means of 1H NMR spectroscopy. In addition, photocleavage studies were also conducted with the plasmid pUC19 and a 158-bp restriction fragment, showing that both diastereomers cleave DNA with similar efficiency, attacking mainly the guanines of the sequence probably by generating active oxygen species. (en) Interakce diastereomerních komplexů delta-[Ru(bpy)2(m-GHK)]Cl2 a lambda-[Ru(bpy)2(m-GHK)]Cl2 (bpy je 2,2'-bipyridine, GHK je glycine-1-histidine-1-lysine) s deoxyribonukleotidovým duplexem d(5'-CGCGATCGCG)2 byla charakterizována pomocí 1H NMR spectroscopie. Kromě toho byly provedeny fotolytické studie s plasmidovou DNA pUC19 a restrikčním fragmentem dlouhým 158 párů bází, které ukázaly, že oba diastereomery štěpí DNA s podobnou účinností zejména v místech guaninových zbytků pravděpodobně za vzniku aktivních forem kyslíku. (cs)
Title	NMR analysis of duplex d(CGCGATCGCG)2 modified by lambda- and delta-[Ru(bpy)2(m-GHK)]Cl2 and DNA photocleavage study NMR analysis of duplex d(CGCGATCGCG)2 modified by lambda- and delta-[Ru(bpy)2(m-GHK)]Cl2 and DNA photocleavage study (en) Analýza pomocí NMR duplexu d(CGCGATCGCG)2 modifikovaného komplexy lambda- a delta-[Ru(bpy)2)m-GHK)]Cl2 a studie fotolýzy DNA (cs)
skos:prefLabel	NMR analysis of duplex d(CGCGATCGCG)2 modified by lambda- and delta-[Ru(bpy)2(m-GHK)]Cl2 and DNA photocleavage study NMR analysis of duplex d(CGCGATCGCG)2 modified by lambda- and delta-[Ru(bpy)2(m-GHK)]Cl2 and DNA photocleavage study (en) Analýza pomocí NMR duplexu d(CGCGATCGCG)2 modifikovaného komplexy lambda- a delta-[Ru(bpy)2)m-GHK)]Cl2 a studie fotolýzy DNA (cs)
skos:notation	RIV/68081707:_____/07:00081006!RIV07-AV0-68081707
http://linked.open.../vavai/riv/strany	279;292
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1P05OC072), P(1QS500040581), P(GA305/05/2030), P(KAN200200651), P(KJB400040601), P(LC06030), Z(AV0Z50040507)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Brabec, Viktor Malina, Jaroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	437392
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/07:00081006
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Ru(II); peptide; DNA photocleavage (en)
http://linked.open.../riv/klicoveSlovo	DNA photocleavage Ru(II) peptide
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[F9D8F7A00F67]
http://linked.open...i/riv/nazevZdroje	Journal of Biological Inorganic Chemistry
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Non-covalent DNA recognition strategies for design and synthesis of new metallo-drugs Metallodrugs, design and mechansim of action Recognition of DNA modified by antitumor platinum and ruthenium complexes by zinc-finger proteins and topoisomerases New approaches to cancer chemotherapy by metal-based drugs Nanoparticulate and supramolecular systems for targeted drug delivery Biomolecular centre
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	12
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Garoufis, A. Malina, Jaroslav Hadjiliadis, N. Myari, A.
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems
issn	0949-8257
number of pages	14 (xsd:int)

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