| Attributes | Values |
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| rdf:type
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| Description
| - Charakterizovali jsme molekulární profil posttranslačních modifikací alfa-tubulinu u normálních epiteliálních buněk prostaty (PrEC), imortalizovaných normálních epiteliálních buněk prostaty J(PZ-HPV-7), nádorových buněk citlivých na androgeny (LNCaP), přechodně na androgenech nezávislých buJňkách (LNCaP-cds, CWR22Rv1) a na androgenech nezávislých prostatických buněk (PC3). V porovnání s PrEC a PZ-HPV-7 měly všechny nádorové buňky zvýšenou hladinu detyrosinovaného a polyglutamylovaného alfa-tubulinu, což korelovalo se sníženou hladinou tubulin tyrosin ligázy. Naopak PrEC a PZ-HPV-7 buňky měly vyšší expresi delta2-tubulinu. Tato data odhalují nové biomarkery nádorových onemocnění prostaty a nový možný cíl terapie. (cs)
- We characterized the molecular profile of alpha-tubulin posttranslational modifications in normal human prostate epithelial cells (PrEC), immortalized normal prostate epithelial cells (PZ-HPV-7), androgen-dependent prostate cancer cells (LNCaP), transitional androgen-independent prostate cancer cells (LNCaP-cds and CWR22Rv1), and androgen-independent prostate cancer cells (PC3). Compared to PrEC and PZ-HPV-7 cells, all cancer cells exhibited elevated levels of detyrosinated and polyglutamylated alpha-tubulin, that was paralleled by decreased protein levels of tubulin tyrosine ligase (TTL). In contrast, PrEC and PZ-HPV-7 cells expressed markedly higher levels of Delta2-tubulin. These data may reveal novel biomarkers of prostate cancer and new therapeutic targets.
- We characterized the molecular profile of alpha-tubulin posttranslational modifications in normal human prostate epithelial cells (PrEC), immortalized normal prostate epithelial cells (PZ-HPV-7), androgen-dependent prostate cancer cells (LNCaP), transitional androgen-independent prostate cancer cells (LNCaP-cds and CWR22Rv1), and androgen-independent prostate cancer cells (PC3). Compared to PrEC and PZ-HPV-7 cells, all cancer cells exhibited elevated levels of detyrosinated and polyglutamylated alpha-tubulin, that was paralleled by decreased protein levels of tubulin tyrosine ligase (TTL). In contrast, PrEC and PZ-HPV-7 cells expressed markedly higher levels of Delta2-tubulin. These data may reveal novel biomarkers of prostate cancer and new therapeutic targets. (en)
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| Title
| - Normal and prostate cancer cells display distinct molecular profiles of alpha-tubulin posttranslational modifications
- Normal and prostate cancer cells display distinct molecular profiles of alpha-tubulin posttranslational modifications (en)
- Normální a nádorové buňky prostaty mají rozdílný profil posttranslačních modifikací alfa-tubulinu (cs)
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| skos:prefLabel
| - Normal and prostate cancer cells display distinct molecular profiles of alpha-tubulin posttranslational modifications
- Normal and prostate cancer cells display distinct molecular profiles of alpha-tubulin posttranslational modifications (en)
- Normální a nádorové buňky prostaty mají rozdílný profil posttranslačních modifikací alfa-tubulinu (cs)
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| skos:notation
| - RIV/68081707:_____/06:00087628!RIV08-AV0-68081707
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/06:00087628
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - prostate cancer; microtubules; detyrosination (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Kubala, Lukáš
- Souček, Karel
- Eiserich, J. P.
- Bulinski, J. Ch.
- Harper, R. W.
- Kamaid, A.
- Phung, A. D.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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