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| rdf:type
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| Description
| - Proliferace hladkých svalových buněk z krysí aorty indukovaná sérem byla přechodně spojena s detyrosinací, ale ne acetylací alfa-tubulinu. Přidání 3-nitro-l-tyrosinu (NO(2)Tyr) do kultivačního média způsobilo selektivní nitrotyrosinaci alfa-tubulinu spojenou se snížením množství Glu-tubulinu, sníženou expresí cyklinu A a E, sníženou asociací EB1 proteinu s plus konci mikrotubulů a inhibicí proliferace. Nitrotyrosinace alfa-tubulinu neindukovala nekrózu ani apoptózu hladkých svalových buněk z krysí aorty, ale namísto toho docházelo k zástavě buněčného cyklu na přechodu G1/S fáze a ke snížení syntézy DNA. Všeobecně tyto výsledky naznačují, že C-konec alfa-tubulinu a jeho detyrosinace jsou funkčně důležitým regulátorem progrese buněčného cyklu u vaskulárních buněk hladkého svalstva. (cs)
- Proliferation of rat aortic smooth muscle cells in response to serum was temporally associated with the detyrosination of alpha-tubulin, but not acetylation of alpha-tubulin. Inclusion of 3-nitro-l-tyrosine (NO(2)Tyr) in the culture medium resulted in the selective nitrotyrosination of alpha-tubulin, that was paralleled by decreased elaboration of Glu-tubulin, decreased expression of cyclins A and E, decreased association of the microtubule plus-end binding protein EB1, and inhibited cell proliferation. Nitrotyrosination of alpha-tubulin did not induce necrotic or apoptotic death of rat aortic smooth muscle cells, but instead led to cell cycle arrest at the G(1)/S boundary coincident with decreased DNA synthesis. Collectively, these results suggest that the C-terminus of alpha-tubulin and its detyrosination are functionally important as a molecular switch that regulates cell cycle progression in vascular smooth muscle cells.
- Proliferation of rat aortic smooth muscle cells in response to serum was temporally associated with the detyrosination of alpha-tubulin, but not acetylation of alpha-tubulin. Inclusion of 3-nitro-l-tyrosine (NO(2)Tyr) in the culture medium resulted in the selective nitrotyrosination of alpha-tubulin, that was paralleled by decreased elaboration of Glu-tubulin, decreased expression of cyclins A and E, decreased association of the microtubule plus-end binding protein EB1, and inhibited cell proliferation. Nitrotyrosination of alpha-tubulin did not induce necrotic or apoptotic death of rat aortic smooth muscle cells, but instead led to cell cycle arrest at the G(1)/S boundary coincident with decreased DNA synthesis. Collectively, these results suggest that the C-terminus of alpha-tubulin and its detyrosination are functionally important as a molecular switch that regulates cell cycle progression in vascular smooth muscle cells. (en)
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| Title
| - Posttranslational nitrotyrosination of alpha-tubulin induces cell cycle arrest and inhibits proliferation of vascular smooth muscle cells
- Posttranslační nitrotyrosinace alfa-tubulinu indukuje inhibici proliferace a zástavu buněčného cyklu u hladkých svalových buněk (cs)
- Posttranslational nitrotyrosination of alpha-tubulin induces cell cycle arrest and inhibits proliferation of vascular smooth muscle cells (en)
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| skos:prefLabel
| - Posttranslational nitrotyrosination of alpha-tubulin induces cell cycle arrest and inhibits proliferation of vascular smooth muscle cells
- Posttranslační nitrotyrosinace alfa-tubulinu indukuje inhibici proliferace a zástavu buněčného cyklu u hladkých svalových buněk (cs)
- Posttranslational nitrotyrosination of alpha-tubulin induces cell cycle arrest and inhibits proliferation of vascular smooth muscle cells (en)
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| skos:notation
| - RIV/68081707:_____/06:00087627!RIV08-AV0-68081707
|
| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/06:00087627
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - vascular smooth muscle cells; microtubules; tubulin tyrosine ligase (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - European Journal of Cell Biology
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Kubala, Lukáš
- Souček, Karel
- Eiserich, J. P.
- Bulinski, J. Ch.
- Harper, R. W.
- Phung, A. D.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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