About: DNA modification with cisplatin affects sequence-specific DNA binding of p53 and p73 proteins in a target site-dependent manner

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	DNA modification with the antitumor drug cisplatin inhibits the p53 binding to a synthetic p53CON. Effects of DNA modification with cisplatin on binding of the p53 or p73 proteins to various p53CON's significantly differed, depending on the nucleotide sequence of the given target site. Relative sensitivities of the protein-DNA binding towards the cisplatin DNA treatment correlated with occurrence of sequence motifs forming stable bifunctional adducts with the drug (namely, GG and AG doublets) within the target sites. Formation of the cisplatin adducts within the target sitzes was primarily responsible for inhibition of the p53 or p73 sequence-specific DNA binding. DNA modification with the antitumor drug cisplatin inhibits the p53 binding to a synthetic p53CON. Effects of DNA modification with cisplatin on binding of the p53 or p73 proteins to various p53CON's significantly differed, depending on the nucleotide sequence of the given target site. Relative sensitivities of the protein-DNA binding towards the cisplatin DNA treatment correlated with occurrence of sequence motifs forming stable bifunctional adducts with the drug (namely, GG and AG doublets) within the target sites. Formation of the cisplatin adducts within the target sitzes was primarily responsible for inhibition of the p53 or p73 sequence-specific DNA binding. (en) Modifikace DNA protinádorovým činidlem cisplatinou inhibuje vazbu p53 k syntetickým p53CON. Vliv modifikace DNA cisplatinou na vazbu proteinů p53 a p73 k odlišným p53CON se výrazně liší v závislosti na nukleotidové sekvenci daného cílového místa. Relativní citlivost vazby protein-DNA vůči platinaci DNA koreluje s výskytem sekvenčních motivů uvnitř cílových míst tvořících s cisplatinou stabilní bifunkční dukty (zejména GG a AG dublety). Tvorba cisplatinových duktů uvnitř cílových míst byla primárně zodpovědná za inhibici sekvenčně specifické vazby p53 a p73 na DNA. (cs)
Title	DNA modification with cisplatin affects sequence-specific DNA binding of p53 and p73 proteins in a target site-dependent manner Modifikace DNA cisplatinou ovlivňuje sekvenčně specifickou vazbu proteinů p53 a p73 v závislosti na sekvenci cílového místa (cs) DNA modification with cisplatin affects sequence-specific DNA binding of p53 and p73 proteins in a target site-dependent manner (en)
skos:prefLabel	DNA modification with cisplatin affects sequence-specific DNA binding of p53 and p73 proteins in a target site-dependent manner Modifikace DNA cisplatinou ovlivňuje sekvenčně specifickou vazbu proteinů p53 a p73 v závislosti na sekvenci cílového místa (cs) DNA modification with cisplatin affects sequence-specific DNA binding of p53 and p73 proteins in a target site-dependent manner (en)
skos:notation	RIV/68081707:_____/06:00049374!RIV07-AV0-68081707
http://linked.open.../vavai/riv/strany	4693;4706
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/05/0416), P(NC7574), Z(AV0Z50040507)
http://linked.open...iv/cisloPeriodika	20
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Pečinka, Petr Fojta, Miroslav Pivoňková, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	472117
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/06:00049374
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	tumor suppressor protein p53; protein p73; cisplatin (en)
http://linked.open.../riv/klicoveSlovo	cisplatin protein p73 tumor suppressor protein p53
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[CA57B46E649B]
http://linked.open...i/riv/nazevZdroje	FEBS Journal
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of novel therapeutic strategies through sensitising tumour cells to anti-cancer drugs by targeting p53-kinases and p53 homologues Recognizing DNA damage by Tumor Suppressor Proteins. Effects of Anti - Cancer Drugs.
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	273
http://linked.open...iv/tvurceVysledku	Fojta, Miroslav Pivoňková, Hana Pečinka, Petr Češková, P.
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems
issn	1742-464X
number of pages	14 (xsd:int)

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