About: Interferon-gamma, but not interferon-alpha, induces SOCS 3 expression in human melanoma cell lines

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About: Interferon-gamma, but not interferon-alpha, induces SOCS 3 expression in human melanoma cell lines Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	V této práci jsme zjistili, že ve většině melanomových linií dochází k induikci genu SOCS3 po působení interferonu gama, nikoliv však interferonu alfa. Tento výsledek naznačuje, že signální dráhy indukující expresi SOCS3 interferonem alfa mohou být v melanomových buňkách porušeny. (cs) In this work we have shown that expression of SOCS3 gene was stimulated by interferon gamma in most human melanoma cell lines while interferon alpha was largely inefficient in induction of this gene. The data suggest that melanoma cells might have altered responses to interferon alpha compared to normal melanocytes. In this work we have shown that expression of SOCS3 gene was stimulated by interferon gamma in most human melanoma cell lines while interferon alpha was largely inefficient in induction of this gene. The data suggest that melanoma cells might have altered responses to interferon alpha compared to normal melanocytes. (en)
Title	Interferon-gamma, but not interferon-alpha, induces SOCS 3 expression in human melanoma cell lines Indukce exprese genu SOCS3 po interferonu gama (ale ne alfa) v buněčných liniích maligního melanomu (cs) Interferon-gamma, but not interferon-alpha, induces SOCS 3 expression in human melanoma cell lines (en)
skos:prefLabel	Interferon-gamma, but not interferon-alpha, induces SOCS 3 expression in human melanoma cell lines Indukce exprese genu SOCS3 po interferonu gama (ale ne alfa) v buněčných liniích maligního melanomu (cs) Interferon-gamma, but not interferon-alpha, induces SOCS 3 expression in human melanoma cell lines (en)
skos:notation	RIV/68081707:_____/05:00026056!RIV06-AV0-68081707
http://linked.open.../vavai/riv/strany	481;488
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/03/0370), P(IBS5004010), P(NR8341), Z(AV0Z50040507), Z(MZ00020980501)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2006
http://linked.open...aciTvurceVysledku	Kovařík, Aleš Fojtová, Miloslava
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	525366
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/05:00026056
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	STAT signalling; SOCS negative regulators; malignant melanoma (en)
http://linked.open.../riv/klicoveSlovo	malignant melanoma SOCS negative regulators STAT signalling
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[780A0FB7440E]
http://linked.open...i/riv/nazevZdroje	Melanoma Research
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular and functional cancer-associated perturbances in JAK/STAT/SOCS proteins and in their target genes expression Analysis of STAT 1 and STAT 3 mediated cytokine signaling in normal and cancer cells Development of new diagnostic techniques for oncology
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	15
http://linked.open...iv/tvurceVysledku	Kovařík, Aleš Fojtová, Miloslava Adámková, Lenka Boudný, Vladimír Kovařík, Jan Lauerová, Ludmila
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Biologické, genetické a epidemiologické aspekty malignit a optimalizace diagnosticko-léčebných postupů
issn	0960-8931
number of pages	8 (xsd:int)

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