About: Binding of mutant and wild type p53 proteins to supercoiled DNA

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Binding of mutant and wild type p53 proteins to supercoiled DNA Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Celý standardní protein p53 (wtp53) může interagovat s DNA svou centrální doménou (CD) nebo C-koncovou doménou (CTD) a touto se váže selektivně s superhelikální DNA (SCS vazba). Tato superhelikálně selektivní vazba byla studována pomocí protilátek. Většina nejčastěji se vyskytujících mutantních proteinů p53 ztrácí schopnost sekvenčně specifické vazby, ale stále je schopna aktivovat či potlačovat cílové geny (vlastní mutantním proteinům) a dále jsou mutantní proteiny schopny interagovat selektivně s non-B DNA elementy (např. MAR/SAR oblasti a stem-loop struktury). (cs) Full length wild-type p53 (wtp53) can interact with DNA via its central (CD) or C-terminal (CTD) domains and it binds selectively to supercoiled DNA (SCS binding) regardless of the presence or absence of the p53 consensus sequence (p53CON). The SCS binding was studied using selective modulation of the CD and CTD by oxidation agents and monoclonal antibodies. Majority of the hot spot mutant p53 proteins (mutp53) lost the SCS binding, but they can still induce or repress transcription of mutp53-specific target genes and they exhibit the ability to interact selectively with non-B DNA elements (e.g., MAR/SAR elements and stem-loop structures). Full length wild-type p53 (wtp53) can interact with DNA via its central (CD) or C-terminal (CTD) domains and it binds selectively to supercoiled DNA (SCS binding) regardless of the presence or absence of the p53 consensus sequence (p53CON). The SCS binding was studied using selective modulation of the CD and CTD by oxidation agents and monoclonal antibodies. Majority of the hot spot mutant p53 proteins (mutp53) lost the SCS binding, but they can still induce or repress transcription of mutp53-specific target genes and they exhibit the ability to interact selectively with non-B DNA elements (e.g., MAR/SAR elements and stem-loop structures). (en)
Title	Binding of mutant and wild type p53 proteins to supercoiled DNA Binding of mutant and wild type p53 proteins to supercoiled DNA (en) Vazba mutantní a standardní formy proteinu p53 k nadšroubovicové DNA (cs)
skos:prefLabel	Binding of mutant and wild type p53 proteins to supercoiled DNA Binding of mutant and wild type p53 proteins to supercoiled DNA (en) Vazba mutantní a standardní formy proteinu p53 k nadšroubovicové DNA (cs)
skos:notation	RIV/68081707:_____/05:00023832!RIV06-AV0-68081707
http://linked.open.../vavai/riv/strany	S4;S5
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1K04119), P(GA301/05/0416), Z(AV0Z50040507)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2006
http://linked.open...aciTvurceVysledku	Paleček, Emil Němcová, Kateřina Fojta, Miroslav Pivoňková, Hana Brázdová, Marie Krstic, Dušan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	513801
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/05:00023832
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	wtp53; hot spot mutp53; SCS binding (en)
http://linked.open.../riv/klicoveSlovo	SCS binding hot spot mutp53 wtp53
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[1680E5698F84]
http://linked.open...i/riv/nazevZdroje	Journal of Applied Biomedicine
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of novel therapeutic strategies through sensitising tumour cells to anti-cancer drugs by targeting p53-kinases and p53 homologues Interactions of mutant p53 with genomic DNA in vitro and in vivo
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	3
http://linked.open...iv/tvurceVysledku	Brázdová, Marie Fojta, Miroslav Paleček, Emil Pivoňková, Hana Němcová, Kateřina Walter, K. Deppert, Wolfgang Krstic, Dušan Warnecke, Gabriele Živanovic, Marko
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems
issn	1214-021X
number of pages	2 (xsd:int)

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software